Characterisation of novel obesity-associated mutations in G protein coupled receptor 10 (GPR10). (360G-Wellcome-107216_Z_15_Z)
Targeted deletion of G-protein-coupled receptor 10 (GPR10) causes severe obesity in mice. We have recently identified novel heterozygous mutations in GPR10 using exome sequencing of 1000 UK individuals with severe, early-onset obesity recruited to the Genetics Of Obesity Study (GOOS) cohort. In this project, I propose to undertake the detailed functional and clinical characterisation of GPR10 mutations. These studies will provide novel insights into the role of GPR10 mediated signalling in the regulation of energy balance in humans. Of particular interest, GPR10 has been identified as a potential drug target for obesity.
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Grant Details
Amount Awarded | 188864 |
Applicant Surname | Talbot |
Approval Committee | Clinical Interview Committee |
Award Date | 2015-02-26T00:00:00+00:00 |
Financial Year | 2014/15 |
Grant Programme: Title | Research Training Fellowship |
Internal ID | 107216/Z/15/Z |
Lead Applicant | Dr Fleur Talbot |
Partnership Value | 188864 |
Planned Dates: End Date | 2017-09-30T00:00:00+00:00 |
Planned Dates: Start Date | 2015-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |
Sponsor(s) | Prof (Ismaa) Sadaf Farooqi |