Characterisation of novel obesity-associated mutations in G protein coupled receptor 10 (GPR10). (360G-Wellcome-107216_Z_15_Z)

£188,864

Targeted deletion of G-protein-coupled receptor 10 (GPR10) causes severe obesity in mice. We have recently identified novel heterozygous mutations in GPR10 using exome sequencing of 1000 UK individuals with severe, early-onset obesity recruited to the Genetics Of Obesity Study (GOOS) cohort. In this project, I propose to undertake the detailed functional and clinical characterisation of GPR10 mutations. These studies will provide novel insights into the role of GPR10 mediated signalling in the regulation of energy balance in humans. Of particular interest, GPR10 has been identified as a potential drug target for obesity.

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Grant Details

Amount Awarded 188864
Applicant Surname Talbot
Approval Committee Clinical Interview Committee
Award Date 2015-02-26T00:00:00+00:00
Financial Year 2014/15
Grant Programme: Title Research Training Fellowship
Internal ID 107216/Z/15/Z
Lead Applicant Dr Fleur Talbot
Partnership Value 188864
Planned Dates: End Date 2017-09-30T00:00:00+00:00
Planned Dates: Start Date 2015-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England
Sponsor(s) Prof (Ismaa) Sadaf Farooqi