Evolution of Burkholderia pseudomallei and its disease dynamics. (360G-Wellcome-107376_Z_15_Z)
Burkholderia pseudomallei is a soil organism found in many parts of the world. Through direct contact with contaminated soil/water, humans acquire infection and develop melioidosis. The disease, often fatal, displays broad clinical manifestations, with different disease patterns reported from different countries. Little is known about factors influencing the disease outcomes and its geographical signatures. We hypothesise that bacterial genetics contribute to disease outcomes, and specificity th at (i) bacterial factors impact on acquisition, disease manifestations and severity; and that (ii) the prevalence of such factors are not homogenously distributed in bacterial populations in different endemic areas. A total of 985 B. pseudomallei whole genome sequences will be employed to address these hypotheses. A phylogeny constructed from 204 global isolates will highlight geographically distinct lineages and their evolutionary timeline. Routes of infection and progression to disease will be related to genetic relatedness of 331 disease and 450 environmental isolates collected from a circumscribed area in Thailand. Clinical manifestations linked to disease isolates will allow us to identify bacterial genetic factors associated with disease specificity, as to consider their prevalence in other geographical locations. Genetic variants predicted in silico will be tested in the zebrafish embryo infection model to validate computational hypotheses.
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Grant Details
Amount Awarded | 250000 |
Applicant Surname | Chewapreecha |
Approval Committee | Basic Science Interview Committee |
Award Date | 2015-04-13T00:00:00+00:00 |
Financial Year | 2014/15 |
Grant Programme: Title | Sir Henry Wellcome Postdoctoral Fellowship |
Internal ID | 107376/Z/15/Z |
Lead Applicant | Miss Kamolchanok Chewapreecha |
Partnership Value | 250000 |
Planned Dates: End Date | 2019-05-31T00:00:00+00:00 |
Planned Dates: Start Date | 2015-06-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |
Sponsor(s) | Prof Gordon Dougan, Prof Nicholas Day, Prof Sharon Peacock |