A small RNA based innate immune system guards germ cell genomes. (360G-Wellcome-110161_Z_15_Z)
One of the most fundamental biological imperatives is faithful transmission of the genome from parent to progeny. Parasitic mobile genetic elements (transposons) threaten this process, and represent one of the most pervasive embodiments of the host-parasite relationship. Their drive is to propagate in germ cells, yet failure of the host to control even a single transposon can lead to sterility1,2. Our central goal is to understand how animals defend germ cell genomes against transposons.
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Grant Details
Amount Awarded | 3190560 |
Applicant Surname | Hannon |
Approval Committee | Science Interview Panel |
Award Date | 2015-12-02T00:00:00+00:00 |
Financial Year | 2015/16 |
Grant Programme: Title | Investigator Award in Science |
Internal ID | 110161/Z/15/Z |
Lead Applicant | Prof Greg Hannon |
Partnership Value | 3190560 |
Planned Dates: End Date | 2024-01-31T00:00:00+00:00 |
Planned Dates: Start Date | 2016-08-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |