A small RNA based innate immune system guards germ cell genomes. (360G-Wellcome-110161_Z_15_Z)

£3,190,560

One of the most fundamental biological imperatives is faithful transmission of the genome from parent to progeny. Parasitic mobile genetic elements (transposons) threaten this process, and represent one of the most pervasive embodiments of the host-parasite relationship. Their drive is to propagate in germ cells, yet failure of the host to control even a single transposon can lead to sterility1,2. Our central goal is to understand how animals defend germ cell genomes against transposons.

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Grant Details

Amount Awarded 3190560
Applicant Surname Hannon
Approval Committee Science Interview Panel
Award Date 2015-12-02T00:00:00+00:00
Financial Year 2015/16
Grant Programme: Title Investigator Award in Science
Internal ID 110161/Z/15/Z
Lead Applicant Prof Greg Hannon
Partnership Value 3190560
Planned Dates: End Date 2024-01-31T00:00:00+00:00
Planned Dates: Start Date 2016-08-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England