Personalised adjunctive anti-inflammatory therapy to reduce deaths from tuberculosis. (360G-Wellcome-110179_Z_15_Z)
A. In HIV-uninfected individuals with tuberculous meningitis: 1. Should adjunctive corticosteroid treatment be personalised according to LTA4H genotype? 2. Are there additional host-derived genotypic or phenotypic predictors of corticosteroid treatment response? 3. Do host-derived genotypic and phenotypic predictors of corticosteroid response in Vietnamese people apply to different populations? B. In HIV-infected individuals with tuberculous meningitis: 4. Is there benefit from adjunctiv e corticosteroids and are there host-derived genotypic and phenotypic predictors of treatment response? C. In HIV-uninfected and HIV-infected individuals with pulmonary tuberculosis: 5. Do LTA4H genotype and other genotypic and/or phenotypic predictors of tuberculous meningitis treatment response identified from Questions A2 and B4 predict clinical phenotype, response to treatment and outcome?
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Grant Details
Amount Awarded | 2563000 |
Applicant Surname | Thwaites |
Approval Committee | Science Interview Panel |
Award Date | 2015-12-02T00:00:00+00:00 |
Financial Year | 2015/16 |
Grant Programme: Title | Investigator Award in Science |
Internal ID | 110179/Z/15/Z |
Lead Applicant | Prof Guy Thwaites |
Partnership Value | 2563000 |
Planned Dates: End Date | 2024-03-31T00:00:00+00:00 |
Planned Dates: Start Date | 2016-04-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South East |