Investigating the structure and functional role of gut tertiary lymphoid organs in inflammation (360G-Wellcome-201224_Z_16_Z)

£261,485

Regulatory T cells play a key role in controlling the inflammatory response in the intestine but little is known about their positioning in the tissue in relation to the T effector and antigen presenting cell populations that they control. Tertiary lymphoid organs (TLOs) are organised lymphoid aggregates which are present in gut under homeostatic and inflammatory conditions. Currently little is known about the natural history of TLO’s during the initiation and perpetuation of bacteria-driven intestinal inflammation and their relationship to the antigen specific effector and regulatory T cell response. Here using state of the imaging technologies and novel methods to track bacteria-reactive T cells we will: 1) Characterise the natural history of TLO’s and their relationship to the regulatory and effector T cell response in intestinal inflammation and repair. 2) Use micro-array analysis of total gene expression of TLOs using laser capture microdissection to identify key pathways that control the TLO response. 3) Investigate cell trafficking within TLOs through blocking of known cytokine and receptor pathways using live imaging. These studies will shed light on the functional role of TLO’s in intestinal homeostasis and inflammation, and may identify interventions that manipulate TLO’s as novel therapeutic targets.

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Grant Details

Amount Awarded 261485
Applicant Surname Gu
Approval Committee Clinical Interview Committee
Award Date 2016-03-02T00:00:00+00:00
Financial Year 2015/16
Grant Programme: Title Research Training Fellowship
Internal ID 201224/Z/16/Z
Lead Applicant Dr Yisu Gu
Partnership Value 261485
Planned Dates: End Date 2019-11-07T00:00:00+00:00
Planned Dates: Start Date 2016-11-07T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East
Sponsor(s) Prof Fiona Powrie