The functional architecture of cerebellar computation (360G-Wellcome-201225_Z_16_Z)

£3,514,421

The goal of this proposal is to define the fundamental units of computation relevant to behaviour in an accessible and important neural circuit of the mammalian brain, the cerebellar cortex. We will use an unprecedented combination of tools – including multiple patch-clamp recordings, high-throughput electron microscopy, 2-photon population imaging and optogenetics – to make decisive tests of longstanding theories of computations carried out by the circuitry of the cerebellar cortex. We will identify and functionally characterize connectivity motifs within mouse cerebellar cortex, investigate how these motifs are engaged by sensory and motor inputs, and test how they can serve as building blocks for computations required for sensorimotor integration. In parallel, we will examine how these circuit motifs are engaged in the intact cerebellar network in awake, headfixed animals, using novel quantitative behavioural assays in order to link circuit activity patterns with sensorimotor integration and plasticity. Finally, we will forge causal links between engagement of specific circuit elements and behaviour, using a novel ‘all-optical’ approach for reading out and manipulating activity in cerebellar circuits to regulate cerebellar plasticity and behavioural performance in both wild type mice and in cerebellar ataxia and autism mutants.

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Grant Details

Amount Awarded 3514421
Applicant Surname Hausser
Approval Committee Science Interview Panel
Award Date 2016-04-05T00:00:00+00:00
Financial Year 2015/16
Grant Programme: Title Principal Research Fellowship Renewal
Internal ID 201225/Z/16/Z
Lead Applicant Prof Michael Hausser
Partnership Value 3514421
Planned Dates: End Date 2022-04-01T00:00:00+00:00
Planned Dates: Start Date 2016-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Raymond MacAllister