The functional architecture of cerebellar computation (360G-Wellcome-201225_Z_16_Z)
The goal of this proposal is to define the fundamental units of computation relevant to behaviour in an accessible and important neural circuit of the mammalian brain, the cerebellar cortex. We will use an unprecedented combination of tools – including multiple patch-clamp recordings, high-throughput electron microscopy, 2-photon population imaging and optogenetics – to make decisive tests of longstanding theories of computations carried out by the circuitry of the cerebellar cortex. We will identify and functionally characterize connectivity motifs within mouse cerebellar cortex, investigate how these motifs are engaged by sensory and motor inputs, and test how they can serve as building blocks for computations required for sensorimotor integration. In parallel, we will examine how these circuit motifs are engaged in the intact cerebellar network in awake, headfixed animals, using novel quantitative behavioural assays in order to link circuit activity patterns with sensorimotor integration and plasticity. Finally, we will forge causal links between engagement of specific circuit elements and behaviour, using a novel ‘all-optical’ approach for reading out and manipulating activity in cerebellar circuits to regulate cerebellar plasticity and behavioural performance in both wild type mice and in cerebellar ataxia and autism mutants.
Where is this data from?
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Grant Details
Amount Awarded | 3514421 |
Applicant Surname | Hausser |
Approval Committee | Science Interview Panel |
Award Date | 2016-04-05T00:00:00+00:00 |
Financial Year | 2015/16 |
Grant Programme: Title | Principal Research Fellowship Renewal |
Internal ID | 201225/Z/16/Z |
Lead Applicant | Prof Michael Hausser |
Partnership Value | 3514421 |
Planned Dates: End Date | 2022-04-01T00:00:00+00:00 |
Planned Dates: Start Date | 2016-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |
Sponsor(s) | Prof Raymond MacAllister |