Control of limb movements by motor cortical circuit dynamics (360G-Wellcome-202111_Z_16_Z)
The control of limb movements has been richly investigated both at the level of behaviour and in cortical electrophysiology. However, a unified theoretical understanding of how limbs are controlled by collective neuronal dynamics is lacking. The core of this proposal is an analysis-by-synthesis approach to relate the dynamics of the motor cortex to the computational objective of limb control. In this pilot project, we will make use of recent developments in the fields of stochastic optimal control and optimization to build model cortical networks that robustly control reaching movements, in the presence of noise at all processing stages and under key physiological constraints inherent to brain circuits. We will then 1) dissect the dynamical strategies used by the model networks to achieve robust control of limb trajectories, 2) relate the model's activity to cortical electrophysiology, and 3) use the models to guide future experiments (involving optogenetic perturbations during movement planning an execution) in collaboration with Karel Svoboda's lab at Janelia Research Campus. In the long term, such models will provide unique insights into the dynamical regime of the motor cortex and suggest optimal ways of interacting with neuronal populations to restore lost function via closed-loop neuroprosthetics.
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
Amount Awarded | 99500 |
Applicant Surname | Hennequin |
Approval Committee | Science Seeds Advisory Panel |
Award Date | 2016-04-08T00:00:00+00:00 |
Financial Year | 2015/16 |
Grant Programme: Title | Seed Award in Science |
Internal ID | 202111/Z/16/Z |
Lead Applicant | Dr Guillaume Hennequin |
Partnership Value | 99500 |
Planned Dates: End Date | 2018-11-19T00:00:00+00:00 |
Planned Dates: Start Date | 2016-07-20T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |