Psychophysics of predictive motor control: a novel model of post-stroke fatigue (360G-Wellcome-202346_Z_16_Z)
Fatigue in neurological conditions, unlike exercise induced fatigue, is chronic, irreversible and does not arise from altered sensory afferent input from peripheral musculature. A distinctive feature of such fatigue is requirement of high effort for everyday activity. Normally, everyday activity feels relatively effortless. This is due to re-afferent sensory feedback from voluntary movement being attenuated under normal circumstances (sensory attenuation). I propose that neurological perceptual fatigue is a result of poor attenuation of re-afferent sensory feedback making even the simplest of movements feel effortful. Using a combination of behavioural and electroencephalography techniques, in a series of systematic experiments, I will study the interaction between self-reported fatigue, effort, behavioural and neural correlates of sensory attenuation. Furthermore, using brain stimulation techniques I will modulate sensory attenuation to determine the direction of causality between fatigue and neural processing. I will study chronic stroke survivors where post-stroke fatigue is a major problem. Fatigue is commonly seen as a neuropsychiatric symptom in neurological conditions and what I propose is a significant shift away from fatigue as a psychiatric problem and towards neurological fatigue being a sensorimotor disorder. The proposed project is also likely to identify a potential therapeutic target to develop interventions for neurological fatigue.
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Grant Details
Amount Awarded | 905754 |
Applicant Surname | Kuppuswamy |
Approval Committee | Sir Henry Dale Fellowship Interview Committee |
Award Date | 2016-06-01T00:00:00+00:00 |
Financial Year | 2015/16 |
Grant Programme: Title | Sir Henry Dale Fellowship |
Internal ID | 202346/Z/16/Z |
Lead Applicant | Dr Annapoorna Kuppuswamy |
Partnership Name | Royal Society/Wellcome Trust Sir Henry Dale Fellowship |
Partnership Value | 905754 |
Planned Dates: End Date | 2022-09-30T00:00:00+00:00 |
Planned Dates: Start Date | 2016-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |
Sponsor(s) | Prof Linda Greensmith |