Human Genetics and Disease Biology: Core Renewal for the Wellcome Trust Centre for Human Genetics (360G-Wellcome-203141_Z_16_Z)

Human genetics provides a unique and powerful tool for understanding normal biology, disease pathophysiology, and infectious mechanisms. The "genetic revolution" of the last decade has witnessed an explosion in knowledge of associated variants for individual traits. Looking forward, large population resources will facilitate a new paradigm, going from variants (individually or collectively) to multiple phenotypes, and new functional tools will help unlock causal genes and mechanisms. In parallel, genome sequencing will become routine in parts of clinical medicine. The Wellcome Trust Centre for Human Genetics (WTCHG), a large interdisciplinary research centre comprising 400 scientists in ~45 research groups, is one of the leading institutes, globally, in human genetics. Since its founding 21 years ago, the WTCHG has played a pioneering role in the progress and success of human disease genetics and mechanism research. Our focus is the development and implementation of novel approaches to exploit human genetics and uncover disease biology so as to improve healthcare. Critical to the Centre’s success is its lively environment which fosters collaborations between research groups across disciplinary boundaries, with research supported by seven Core teams. This application seeks core support to enable the WTCHG to continue its leading role in the field.