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Molecular Control of Adhesion-Free Migration (360G-Wellcome-204747_Z_16_Z)

Many cells have the capacity of directed motion, which is essential for several physiological and pathological processes, including development, immune-response, and metastasis. During canonical, focal adhesion-based migration, actin dynamics are converted to traction force through integrin-based anchors to the substrate. However, integrins are dispensable for in vivo and 3D-confined migration of various cell types. Recently, an alternative migration mode was discovered, during which propulsion forces are generated through non-specific friction between the cell cortex and its substrate. However, nothing is known about the molecular mechanism underlying friction-driven migration. I will elucidate this process, first by performing a candidate-based screen and state-of-the-art microfabrication assays to identify the molecules responsible for generating friction. Next, I will create knock-out zebrafish lines to determine the in vivo relevance of friction-driven migration. Finally, I will study how cells transition between adhesive and adhesion-free migration, which is crucial e.g. during cancer progression. To identify the key processes underlying these transitions, I will perform live cell microscopy of friction-generating and adhesion molecules and integrate my findings into a mathematical model of cell migration. Ultimately, this project will shed light on a newly uncovered migration mode that is likely of fundamental importance for in vivo cell motility.


09 Nov 2016

Grant details
Amount Awarded 250000
Applicant Surname Bodor
Approval Committee Basic Science Interview Committee
Award Date 2016-11-09T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Sir Henry Wellcome Postdoctoral Fellowship
Internal ID 204747/Z/16/Z
Lead Applicant Dr Dani Bodor
Planned Dates: End Date 2021-02-01T00:00:00+00:00
Planned Dates: Start Date 2017-02-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Mark Marsh
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