Which maternal infections are associated with stillbirths and early neonatal deaths, in East Africa? (360G-Wellcome-205184_Z_16_Z)

Reducing neonatal deaths and stillbirths is an international public health priority, yet the contribution of vertically-acquired infection, potentially amenable to intervention, is unclear, with essentially no data from the highest mortality settings. I propose to provide a robust description of the association of maternal infection with stillbirths and early neonatal deaths by studying mothers delivering in a moderate mortality setting in Kilifi, Kenya, and in Harar, Ethiopia, where the under-5 mortality ratio is three-fold higher than in Kilifi, Kenya. I will begin by investigating mothers in Kilifi County Hospital, Kenya, from a well-characterised existing maternal cohort (2011-16) in a case-control design (n=700). Laboratory investigation using nucleic acid detection on stored blood samples will be done at the internationally accredited KEMRI-Wellcome Trust Research Programme laboratories. Then, in a prospective study in Hiwot Fana Hospital, Harar, Ethiopia, I will recruit and investigate mothers (2017-19) in the same case-control design (n=700). Laboratory investigation on site will include both conventional and nucleic acid detection methods. This study utilises a new site for the Child Health and Mortality Prevention Surveillance (CHAMPS) network. As this network extends, it will create the opportunity to use this work to design community studies and large scale intervention trials.

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Grant Details

Amount Awarded 578385
Applicant Surname Seale
Approval Committee Clinical Interview Committee
Award Date 2016-12-06T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Clinical Research Career Development Fellowship
Internal ID 205184/Z/16/Z
Lead Applicant Dr Anna Seale
Partnership Value 578385
Planned Dates: End Date 2021-09-30T00:00:00+00:00
Planned Dates: Start Date 2017-03-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Anthony Scott