Utilising electronic health records and Mendelian randomisation to investigate the relationship between liver function biomarkers and gastrointestinal disease; an example of bilirubin (360G-Wellcome-206274_Z_17_Z)

£253,846

Liver function tests (LFTs) are commonly performed in clinical practice and are often associated with malignant and inflammatory diseases. Bilirubin has an anti-oxidant, cytoprotective function, and reported inverse associations with conditions including cardiovascular disease, inflammatory bowel disease, colorectal cancer and overall mortality. We will use linked primary care, hospitalisation, disease registry and mortality data in England (the CALIBER programme), [1] and include people aged 18 or older with no underlying gastrointestinal disease at baseline. We will use Cox models to estimate cause-specific hazard ratios (HRs) for the association of baseline bilirubin with onset of gastrointestinal disease. We will further compare outcomes in gastrointestinal disease and malignancy cohorts including hospitalisation rates, relapse-free survival, net survival and mortality. Finally, we will determine whether the associations detected (with serum bilirubin) are likely to be causal by utilising a Mendelian randomisation approach.

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Grant Details

Amount Awarded 253846
Applicant Surname Parisinos
Approval Committee Internal Decision Panel
Award Date 2017-09-30T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title PhD Training Fellowship for Clinicians
Internal ID 206274/Z/17/Z
Lead Applicant Dr Constantinos Parisinos
Partnership Value 253846
Planned Dates: End Date 2019-12-01T00:00:00+00:00
Planned Dates: Start Date 2016-12-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London