Towards an individualised, mechanistic understanding of resilience to mental illness during development: the role of affective processing in adolescence (360G-Wellcome-206459_Z_17_Z)
This project examines how individual differences in affective processing contribute to the development of psychiatric traits in adolescence. My two-pronged approach tackles this question from complimentary angles: 1) applying sophisticated statistical methods to currently-available large-scale data to understand individual differences in affective processing and 2) developing more sensitive measures of these individual differences. I will build upon statistical techniques for large-scale data analysis utilising two existing cohorts of adolescents/young adults (Objective 1). Using Structural Equation Modelling, I will investigate how individual differences in multi-level longitudinal measures of affective processing map onto risk for the development of mental illness. Second, I will use computational and psychophysics approaches to build upon established computational models of face perception. I will develop a facial emotion-processing task to quantify individual differences in emotion perception and assess the degree of variability in an individuals’ emotion perception (Objective 2a). I will then relate this variability to individual differences in behavioural traits associated with common mental health difficulties including anxiety and conduct problems (Objective 2b). Together, these approaches link large-scale investigation of mechanisms (Objective 1) with a more refined way of measuring individual differences in these mechanisms (Objective 2) to understand vulnerability to mental illness in adolescence.
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Grant Details
Amount Awarded | 250000 |
Applicant Surname | Carlisi |
Approval Committee | Basic Science Interview Committee |
Award Date | 2017-04-19T00:00:00+00:00 |
Financial Year | 2016/17 |
Grant Programme: Title | Sir Henry Wellcome Postdoctoral Fellowship |
Internal ID | 206459/Z/17/Z |
Lead Applicant | Dr Christina Carlisi |
Partnership Value | 250000 |
Planned Dates: End Date | 2022-08-31T00:00:00+00:00 |
Planned Dates: Start Date | 2017-09-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |
Sponsor(s) | Prof Essi Viding |