Schwann cell-axonal communication during axonal degeneration and regrowth (360G-Wellcome-206634_Z_17_Z)
Myelinating and non-myelinating Schwann cells are reprogrammed after nerve injury into repair Schwann cells, specialized for maintaining survival of injured neurons and supporting axonal regeneration. This process is regulated by Schwann cell-intrinsic signals, such as the transcription factor c-Jun, however few other candidates have been identified. It is, currently, unknown how Schwann cell reprogramming is initiated, but unidentified extrinsic signals from injured axons are likely candidates. I aim to delineate the spatial and temporal regulation of Schwann cell-intrinsic downstream signals in real-time and define their role in repair Schwann cell function and axonal regeneration. Secondly, I aim to test the hypothesis that axon-derived signals initiate Schwann cell reprogramming during nerve injury. I will use cell culture, in vivo mouse models and a live and dynamic zebrafish larval model of nerve injury. This study will be the first to investigate how axon-intrinsic mechanisms of nervous system injury interplay with glial cell molecular responses to nerve damage, in real-time. Using cutting edge techniques in two species, this project will significantly advance our understanding of Schwann cell-axonal biology and tissue repair. Excitingly, this research may identify new potential therapeutic targets to improve poorly regenerating human nerves and treat patients with neuropathies.
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Grant Details
Amount Awarded | 426876 |
Applicant Surname | Arthur-Farraj |
Approval Committee | Clinical Interview Committee |
Award Date | 2017-05-25T00:00:00+00:00 |
Financial Year | 2016/17 |
Grant Programme: Title | Clinical Research Career Development Fellowship |
Internal ID | 206634/Z/17/Z |
Lead Applicant | Dr Peter Arthur-Farraj |
Partnership Value | 426876 |
Planned Dates: End Date | 2023-05-11T00:00:00+00:00 |
Planned Dates: Start Date | 2017-09-11T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |
Sponsor(s) | Prof Michael Coleman |