Contextual determinants of surprise in health, development and disorder. (360G-Wellcome-206691_Z_17_Z)

£983,275

The goal of this research proposal is to build a theoretical and experimental framework to understand the contextual determinants of "surprise" (expectation violations/prediction errors) in health, development, and disorder. I have the following three aims: 1) To exploit high-field neuroimaging and pharmacological manipulations in healthy adults to reveal the precise neural mechanisms that alter surprise processing in response to volatility, and validate different pupil metrics as a window into central neuromodulatory function. 2) To conduct model-based neuroimaging in infants, for the first time, to predict risk for the dimensional symptoms of autism, and reveal the computational neurodevelopment of probabilistic and volatility learning in infants. 3) To develop a unified computational framework of surprise-driven learning that has the specificity to reveal separable mechanisms of psychopathology in different neuropsychiatric conditions and the potential to be used as a clinical tool. To achieve these objectives I will utilise the same cognitive tasks, pupillometric measurements and computational models of learning across three research themes. This ensures that while the individual projects are strongly hypothesis-driven the findings can be directly translated across developmental, adult, and disordered states. Key words: autism, neurodevelopment, predictive coding, surprise, computational models, 7T fMRI, pharmacology, noradrenaline, psychosis.

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Grant Details

Amount Awarded 983275
Applicant Surname Lawson
Approval Committee Sir Henry Dale Fellowship Interview Committee
Award Date 2017-05-31T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Sir Henry Dale Fellowship
Internal ID 206691/Z/17/Z
Lead Applicant Dr Rebecca Lawson
Partnership Name Royal Society/Wellcome Trust Sir Henry Dale Fellowship
Partnership Value 983275
Planned Dates: End Date 2024-06-07T00:00:00+00:00
Planned Dates: Start Date 2018-02-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England
Sponsor(s) Prof Mark Johnson, Prof Trevor Robbins