Contextual determinants of surprise in health, development and disorder. (360G-Wellcome-206691_Z_17_Z)
The goal of this research proposal is to build a theoretical and experimental framework to understand the contextual determinants of "surprise" (expectation violations/prediction errors) in health, development, and disorder. I have the following three aims: 1) To exploit high-field neuroimaging and pharmacological manipulations in healthy adults to reveal the precise neural mechanisms that alter surprise processing in response to volatility, and validate different pupil metrics as a window into central neuromodulatory function. 2) To conduct model-based neuroimaging in infants, for the first time, to predict risk for the dimensional symptoms of autism, and reveal the computational neurodevelopment of probabilistic and volatility learning in infants. 3) To develop a unified computational framework of surprise-driven learning that has the specificity to reveal separable mechanisms of psychopathology in different neuropsychiatric conditions and the potential to be used as a clinical tool. To achieve these objectives I will utilise the same cognitive tasks, pupillometric measurements and computational models of learning across three research themes. This ensures that while the individual projects are strongly hypothesis-driven the findings can be directly translated across developmental, adult, and disordered states. Key words: autism, neurodevelopment, predictive coding, surprise, computational models, 7T fMRI, pharmacology, noradrenaline, psychosis.
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Grant Details
Amount Awarded | 983275 |
Applicant Surname | Lawson |
Approval Committee | Sir Henry Dale Fellowship Interview Committee |
Award Date | 2017-05-31T00:00:00+00:00 |
Financial Year | 2016/17 |
Grant Programme: Title | Sir Henry Dale Fellowship |
Internal ID | 206691/Z/17/Z |
Lead Applicant | Dr Rebecca Lawson |
Partnership Name | Royal Society/Wellcome Trust Sir Henry Dale Fellowship |
Partnership Value | 983275 |
Planned Dates: End Date | 2024-06-07T00:00:00+00:00 |
Planned Dates: Start Date | 2018-02-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |
Sponsor(s) | Prof Mark Johnson, Prof Trevor Robbins |