The role of protein kinases in the regulation of Rif1 during DNA damage and spindle damage in eukaryotic cells (360G-Wellcome-207143_Z_17_Z)
Rif1 (Rap1-Interacting Factor 1) protein is a well-conserved DNA-damage-response factor, required for cell survival after DNA damage and for proper execution of DNA replication. Little is known about how does Rif1 achieve these functions or how it is regulated. This project will investigate potential roles for certain protein kinases, in phosphorylating Rif1 in response to telomere and spindle damage. The protein kinases will be selected from a list of factors demonstrated to interact with Rif1 in high throughput assays. The key goal is to Identify the protein(s) phosphorylating Rif1, which may help us understand the mechanisms by which telomere dysfunction is involved in carcinogenesis.
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Grant Details
| Amount Awarded |
0
|
| Applicant Surname | Luncanu |
| Approval Committee | Internal Decision Panel |
| Award Date | 2017-04-27T00:00:00+00:00 |
| Financial Year | 2016/17 |
| Grant Programme: Title | Vacation Scholarships |
| Internal ID | 207143/Z/17/Z |
| Lead Applicant | Mr Catalin Luncanu |
| Partnership Value | 0 |
| Planned Dates: End Date | 2017-08-11T00:00:00+00:00 |
| Planned Dates: Start Date | 2017-06-12T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | North East |