Haemocompatibility and biocompatibility of a polyurethane-based polymer for use in prosthetic heart valves (360G-Wellcome-207161_Z_17_Z)

Developing valves with efficient function and long-term durability without the need for anticoagulation therapy, coupled with the ability to be accommodated in many different types of patient, are the principal requirements of replacement heart valves. The current treatment options available do not fit well with these critieria. The overall aim of the project is to develop a biomimetic polymer alternative to pericardium heart valve leaflets with a more repeatable, consistent and predictable production process. Main research objective: To investigate the haemocompatability of the polymer valve. That is, to measure the blood's response to contact with the valve by measuring parameters such as thrombogenicity, activation of coagulation, blood cell countsand platelet activation. Secondary research objective: To carry out a comprehensive collaborative literature review with my supervisor to deisign an experiment that helps us to understand the blood's response to the polymer in a dynamic environment i.e. simulating the in vivo scenario of blood being pumped across the valve and therefore coming in contact with the valve while under stress. Time allowing, we will then carry out this experiment. We hypothesize that the polyurethane-based material will have equivalent haemocompatibility to that of a commercially available aortic heart valve replacement.