Identification of genes important for susceptibility to taxol-induced apoptosis (360G-Wellcome-207264_Z_17_Z)
CRISPR-based genetic screens have emerged as cutting-edge tools to identify genes important for many processes. Microtubule-disrupting agents, such as paclitaxel (Taxol) and docetaxel (Taxotere), are widely used chemotherapeutic agents that kill highly replicating tumor cells. However, such agents also trigger NFkappaB-dependent responses that can negatively influence tumor clearance by promoting tumor survival and metastasis. Moreover, how transformed cells develop resistance to taxol and related compounds is poorly understood. Here, we wish to use CRISPR-based genome-wide screening methods to screen for genes that, upon inactivation, confer resistance to taxol and related compounds. Identification of genes required for taxol-induced cell death will generate new insights on how taxol initiates apoptosis in tumors as well as potential resistance mechanisms.
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Grant Details
| Amount Awarded |
0
|
| Applicant Surname | O'Callaghan |
| Approval Committee | Internal Decision Panel |
| Award Date | 2017-04-27T00:00:00+00:00 |
| Financial Year | 2016/17 |
| Grant Programme: Title | Vacation Scholarships |
| Internal ID | 207264/Z/17/Z |
| Lead Applicant | Mr Joseph O'Callaghan |
| Partnership Value | 0 |
| Planned Dates: End Date | 2017-09-02T00:00:00+00:00 |
| Planned Dates: Start Date | 2017-07-03T00:00:00+00:00 |
| Recipient Org: Country | Ireland |
| Region | Ireland |