GeneFriends: A gene and transcript co-expression resource (360G-Wellcome-208375_Z_17_Z)

£213,244

GeneFriends is an online (http://genefriends.org/) gene and transcript co-expression resource which allows researchers to assign putative functions to poorly annotated genes/transcripts as well as identify and rank new candidate genes related to any disease or process using a guilt-by-association approach. In this project, we aim to build upon the work done thus far, by maintaining, expanding and enhancing existing resources and by developing new functionalities. Specifically, the goals of this proposal are: 1. Update and enhance the current GeneFriends databases and tools by updating the underlying datasets and developing network visualization features. 2. Allow users to create co-expression networks from their own data uploaded to GeneFriends by developing a suitable pipeline and by implementing a user-friendly web page to return results to users. 3. Allow users to select/add extra gene expression datasets to create customized co-expression networks; this will involve creating a compilation of pre-processed publicly available gene expression data and metadata plus adapting our existing pipelines for data processing and co-expression network construction. Given the growing importance of next-generation sequencing, GeneFriends will greatly benefit the research community. Overall, GeneFriends is a powerful approach for the analysis and interpretation of genetics and genomics data from different types of studies.

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Grant Details

Amount Awarded 213244
Applicant Surname de Magalhaes
Approval Committee Biomedical Resource Committee
Award Date 2017-07-06T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Biomedical Resources Grant
Internal ID 208375/Z/17/Z
Lead Applicant Prof Joao Pedro de Magalhaes
Partnership Value 213244
Planned Dates: End Date 2022-03-31T00:00:00+00:00
Planned Dates: Start Date 2018-08-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region North West