Understanding the link between CpG islands and gene transcription (360G-Wellcome-209400_Z_17_Z)

£2,072,282

CpG islands(CGIs) are epigenetically specified elements that are intimately associated with over two-thirds of human gene promotors, yet whether CGIs regulate gene expression has remained enigmatic. This gap in our understanding of gene promoter function has serious implications for human health given that CGIs are perturbed in cancer and other debilitating human diseases. We have recently discovered that CGIs are recognized by reader proteins which can regulate gene expression. Capitalising on these advances, I will now discover how CGIs and the proteins that read them control the transcriptional machinery at gene promoters. I will achieve this transformative new mechanistic understanding through a multidisciplinary and hypothesis-driven programme of research that builds on a series of exciting new and unpublished observations to discover how CGIs function to activate(Aim1) and maintain(Aim2) transcription, and test whether CGIs create gene expression switches(Aim3). These new discoveries will help to redefine our understanding of how gene promoters function to control gene expression and will provide the basis on which new therapeutic interventions can be developed for diseases where normal CGI biology is perturbed.

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Grant Details

Amount Awarded 2072282
Applicant Surname Klose
Approval Committee Science Interview Panel
Award Date 2017-11-28T00:00:00+00:00
Financial Year 2017/18
Grant Programme: Title Investigator Award in Science
Internal ID 209400/Z/17/Z
Lead Applicant Prof Robert Klose
Partnership Value 2072282
Planned Dates: End Date 2024-07-01T00:00:00+00:00
Planned Dates: Start Date 2018-07-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East