Investigating the impact of seizures on newborn brain (360G-Wellcome-219610_Z_19_Z)
Seizures are a common manifestation of brain injury in newborn infants. Controversies still exist over whether seizures may themselves cause further damage to the developing brain, when to treat them, what drugs to use and how to improve detection. There is an urgent need for a better understanding of the pathophysiological changes to improve our management strategies. My key goal is to assess the impact of seizures on the newborn brain. I propose to use a new optical platform (combined broadband near-infrared spectroscopy and diffusion correlation spectroscopy) for a comprehensive real-time assessment of cerebral metabolism (using oxCCO and CMRO2), haemodynamics (using CBF and CBV) and oxygenation (using TOI) together with video-electroencephalography(EEG) at the cot-side to investigate seizure-induced changes inside brain. I aim to deliver a translational and clinical strategy to investigate these changes in healthy brains of an animal model and in a cohort of babies in neonatal intensive care who developed seizures after brain injury. I will further investigate the impact of phenobarbitone on brain metabolism and haemodynamics. Short and long-term impacts will be assessed with neuroimaging and neurodevelopmental outcome data. These findings will improve our understanding and will support an evidence-based approach for the management of neonatal seizures.
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Grant Details
Amount Awarded | 755905 |
Applicant Surname | Mitra |
Approval Committee | Clinical Interview Committee |
Award Date | 2019-12-05T00:00:00+00:00 |
Financial Year | 2019/20 |
Grant Programme: Title | Clinical Research Career Development Fellowship |
Internal ID | 219610/Z/19/Z |
Lead Applicant | Dr Subhabrata Mitra |
Partnership Value | 755905 |
Planned Dates: End Date | 2024-07-31T00:00:00+00:00 |
Planned Dates: Start Date | 2020-08-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |
Sponsor(s) | Prof Anna David |