Highly sensitive brain blood flow measurements using ultra-high field magnetic resonance imaging (360G-Wellcome-220204_Z_20_Z)

£1,017,466

Blood flow is critical for maintaining the steady supply of oxygen and nutrients to the brain, and blood flow changes are present in a range of diseases including stroke and dementia. Conventional methods for in vivo blood flow mapping have limitations and often cannot be used for longitudinal monitoring or research. In this proposal I aim to develop highly sensitive imaging methods for measuring brain blood flow based on a non-invasive magnetic resonance imaging technique, arterial spin labelling, applied at ultra-high field. The main goals of this research are: To establish a robust platform for ultra-high field arterial spin labelling by developing novel approaches to overcome a range of technical challenges associated with this technique; To develop advanced imaging approaches which allow richer cerebrovascular information to be obtained, including high resolution angiography and vessel-selective imaging; To demonstrate the high sensitivity achievable with these novel methods by measuring changes in white matter perfusion in patients with vascular cognitive impairment, and probing the brain’s response to tonic pain at unprecedented spatial resolution. These new methods will be actively shared with local, national and international collaborators, enabling previously unfeasible clinical and basic science research studies to be performed.

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Grant Details

Amount Awarded 1017466
Applicant Surname Okell
Approval Committee Sir Henry Dale Fellowship Interview Committee
Award Date 2020-03-04T00:00:00+00:00
Financial Year 2019/20
Grant Programme: Title Sir Henry Dale Fellowship
Internal ID 220204/Z/20/Z
Lead Applicant Dr Thomas Okell
Partnership Name Royal Society/Wellcome Trust Sir Henry Dale Fellowship
Partnership Value 1017466
Planned Dates: End Date 2025-06-14T00:00:00+00:00
Planned Dates: Start Date 2020-06-15T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East
Sponsor(s) Prof Heidi Johansen-Berg