Highly sensitive brain blood flow measurements using ultra-high field magnetic resonance imaging (360G-Wellcome-220204_Z_20_Z)
Blood flow is critical for maintaining the steady supply of oxygen and nutrients to the brain, and blood flow changes are present in a range of diseases including stroke and dementia. Conventional methods for in vivo blood flow mapping have limitations and often cannot be used for longitudinal monitoring or research. In this proposal I aim to develop highly sensitive imaging methods for measuring brain blood flow based on a non-invasive magnetic resonance imaging technique, arterial spin labelling, applied at ultra-high field. The main goals of this research are: To establish a robust platform for ultra-high field arterial spin labelling by developing novel approaches to overcome a range of technical challenges associated with this technique; To develop advanced imaging approaches which allow richer cerebrovascular information to be obtained, including high resolution angiography and vessel-selective imaging; To demonstrate the high sensitivity achievable with these novel methods by measuring changes in white matter perfusion in patients with vascular cognitive impairment, and probing the brain’s response to tonic pain at unprecedented spatial resolution. These new methods will be actively shared with local, national and international collaborators, enabling previously unfeasible clinical and basic science research studies to be performed.
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Grant Details
Amount Awarded | 1017466 |
Applicant Surname | Okell |
Approval Committee | Sir Henry Dale Fellowship Interview Committee |
Award Date | 2020-03-04T00:00:00+00:00 |
Financial Year | 2019/20 |
Grant Programme: Title | Sir Henry Dale Fellowship |
Internal ID | 220204/Z/20/Z |
Lead Applicant | Dr Thomas Okell |
Partnership Name | Royal Society/Wellcome Trust Sir Henry Dale Fellowship |
Partnership Value | 1017466 |
Planned Dates: End Date | 2025-06-14T00:00:00+00:00 |
Planned Dates: Start Date | 2020-06-15T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South East |
Sponsor(s) | Prof Heidi Johansen-Berg |