Serological studies to quantify SARS-CoV-2 population infection risk in Singapore, Hong Kong and Thailand (360G-Wellcome-221013_Z_20_Z)

£399,361

We propose a prospective serological study to investigate the incidence of SARS-CoV-2 infection in the general population in three Asian settings: Singapore, Hong Kong and Thailand. The study will aim to measure the age-specific seroprevalence and incidence of SARS-CoV-2 infection at 3 time points, each 6 months apart. Age-specific incidence estimates will be applied to the census population to obtain numbers of infections in the population at each time point. These estimates will be compared with external data on COVID-19 hospitalisations and deaths in each setting, to calculate age-specific infection-hospitalisation and infection-fatality ratios. SARS-CoV-2 antibody kinetics will be defined by studying changes in antibody titres over time. Risk factors for infection will be studied by comparing SARS-CoV-2 seroconverters and non-seroconverters with respect to epidemiological exposures. This study will provide crucial information regarding population exposure and SARS-CoV-2 transmission dynamics, and will provide a complete picture of the relationship between clinically apparent and asymptomatic infections.

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Grant Details

Amount Awarded 399361
Applicant Surname Tam
Approval Committee Epidemic Technical Advisory Panel
Award Date 2020-09-30T00:00:00+00:00
Financial Year 2019/20
Grant Programme: Title Coronavirus
Internal ID 221013/Z/20/Z
Lead Applicant Dr Clarence Tam
Other Applicant(s) Dr Chee Fu Yung, Dr Kathryn Anderson, Dr Stefan Fernandez, Prof Benjamin Cowling, Prof Lin-Fa Wang
Partnership Name Wellcome-DFID Epidemic Preparedness
Partnership Value 823390
Planned Dates: End Date 2022-06-05T00:00:00+00:00
Planned Dates: Start Date 2020-10-01T00:00:00+00:00
Recipient Org: Country Singapore
Region International