Serological studies to quantify SARS-CoV-2 population infection risk in Singapore, Hong Kong and Thailand (360G-Wellcome-221013_Z_20_Z)
We propose a prospective serological study to investigate the incidence of SARS-CoV-2 infection in the general population in three Asian settings: Singapore, Hong Kong and Thailand. The study will aim to measure the age-specific seroprevalence and incidence of SARS-CoV-2 infection at 3 time points, each 6 months apart. Age-specific incidence estimates will be applied to the census population to obtain numbers of infections in the population at each time point. These estimates will be compared with external data on COVID-19 hospitalisations and deaths in each setting, to calculate age-specific infection-hospitalisation and infection-fatality ratios. SARS-CoV-2 antibody kinetics will be defined by studying changes in antibody titres over time. Risk factors for infection will be studied by comparing SARS-CoV-2 seroconverters and non-seroconverters with respect to epidemiological exposures. This study will provide crucial information regarding population exposure and SARS-CoV-2 transmission dynamics, and will provide a complete picture of the relationship between clinically apparent and asymptomatic infections.
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Grant Details
Amount Awarded | 399361 |
Applicant Surname | Tam |
Approval Committee | Epidemic Technical Advisory Panel |
Award Date | 2020-09-30T00:00:00+00:00 |
Financial Year | 2019/20 |
Grant Programme: Title | Coronavirus |
Internal ID | 221013/Z/20/Z |
Lead Applicant | Dr Clarence Tam |
Other Applicant(s) | Dr Chee Fu Yung, Dr Kathryn Anderson, Dr Stefan Fernandez, Prof Benjamin Cowling, Prof Lin-Fa Wang |
Partnership Name | Wellcome-DFID Epidemic Preparedness |
Partnership Value | 823390 |
Planned Dates: End Date | 2022-06-05T00:00:00+00:00 |
Planned Dates: Start Date | 2020-10-01T00:00:00+00:00 |
Recipient Org: Country | Singapore |
Region | International |