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The Wellcome Trust

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Poplar Wellbeing Pavilion 30 Jun 2017

Partners: Poplar HARCA Housing, Trees for Cities, UCL Urban Sustainability & Resilience PhD research, community architects: AzuKo and Rural Studio USA. Through a 4-month programme of inspiring public activities and events, this ground-up initiative explores the complex relationship between wellbeing and the built environment. Sited around a purpose-built pavilion on the Lansbury Estate, Poplar, weekly activities will animate and influence a new community-owned urban space. Dialogue, dancing, fitness, horticulture, literacy and design events, will catalyse exchange and make collaborations visible. Bookended by two major architecture festivals, this project will reach over 2,000 participants and visitors and promote a dialogue between community networks and decision makers in design and health. The project’s scope and ambition is underpinned and made possible through its key partnerships. It aims to: - challenge embedded behaviours, attitudes and beliefs about wellbeing in the city - make local initiatives visible, extending their reach - create inspirational and inclusive activities with and for the public - engage and influence design and healthcare professionals by connecting decision-makers to community action The work will have an extensive reach and legacy. Its impact will be continuously documented and tracked, shared online and folded back into HARCA’s projects and networks.

Amount: £20,000
Funder: The Wellcome Trust
Recipient: No Organisation

Sick(er) R & D and Production 30 May 2017

I’m making feature film, Sick(er). I’m seeking research and development funding for companion documentary shorts of £30k, and £50k for the feature. Over three months of R&D, I’ll draw on my extensive network of scientists, psychiatrists and academic experts to create three documentary shorts with different participants who’ve had EDs beyond the stereotypical subjects. I’ll integrate a level of science and individual social-cultural context in the films. The complex intersection of lived experience and science will be transformative for audiences. The shorts will support the feature development. Sick(er) explores EDs’ impact on family life through an engaging human story. It builds on my success as a novelist and short filmmaker. I’m keen to bring my filmmaking voice to this vital subject now, as it is such an important issue. The companion documentary shorts will function independently but also support the dramatic feature film, in that they’ll connect with audiences through websites; Nowness and Little White Lies. The feature will have appeal to arthouse audiences with potential at international film festivals, followed by crossover to theatrical distribution and home entertainment release. As a BBC Films feature we are guaranteed a screening across their channels and BBC iPlayer.

Amount: £30,000
Funder: The Wellcome Trust
Recipient: Lions Den Films

A Touch of Flu: Centenary of the Spanish Flu Pandemic 30 May 2017

Between the early summer of 1918 and the spring of 1919 the ‘Spanish’ influenza (so-called because Spain was the only country not to censor reports of the spreading epidemic) claimed the lives of a quarter of a million Britons. Worldwide, the death toll from the flu has been estimated at fifty million – ten times as many as died in the First World War and ten million more than AIDS has killed in thirty years. Timed for the centenary of the pandemic in 2018, this project is part of an exciting collaboration between the Florence Nightingale Museum, Queen Mary University of London and the Commonwealth War Graves Commission. ‘A Touch of Flu’ will combine public engagement with academic excellence and will bring together a touring exhibition, a digital resource and an animated short film.

Amount: £82,000
Funder: The Wellcome Trust
Recipient: Florence Nightingale Museum

Last Breath 30 May 2017

Last Breath is the story of how a commercial diver is stranded on the sea-bed with 5 minutes of back up gas, but no chance of rescue for over 30 minutes. Told through compelling interviews, dramatic reconstruction and extraordinary archive, this is the true story of one man’s impossible fight for survival. It is Gravity meets Touching the Void – 100 metres underwater. At the heart of the film is the journey of Chris Lemons from the moment he loses his gas feed to his lifeless body being resuscitated 36 minutes later. During this time he went through several phases of consciousness, and made a series of decisions while under extreme emotional stress as he slowly transitioned into unconsciousness. The complex interaction between his mind and body through-out this period raises many questions relevant to current neuroscientific, physiological and philosophical research? Our scientific consultant is Dr. Tristan Bekinschtein from the University of Cambridge who specialises in the physiology and cognition of consciousness. Netflix and BBC are finanicers, giving Last Breath a huge potential worldwide audience who will engage with a powerful story, the questions it raises about consciousness and what it means to be human. Trailer LB: https://vimeo.com/170593230 Password: fhf

Amount: £30,000
Funder: The Wellcome Trust
Recipient: Met Film Production Ltd

Wings at the Young Vic 30 Apr 2017

The Young Vic has an international reputation for creating ground-breaking shows with the most talented artists. We keep ticket prices low and give 10% away for free to non-traditional audiences. This gives us one of the most exciting, diverse and young audiences in the country. The Young Vic is London’s most lovable theatre. The building welcomes; the programming dares. It offers danger in a safe place. The Observer In Autumn 2017, director Natalie Abrahami will stage Arthur Kopit’s Wings in our main house with renowned actor Juliet Stevenson playing the lead role – a woman experiencing the aftermath of a debilitating stroke. We’ll run a program of activity to widen Wings’ reach and impact, including: - A main house run in September -October 2017 (45 performances). We’ll work with neurologist Dr Paul Jarman, and stroke patients and the show will reach a large and diverse audience. - Three post-show talks, four in-school and two on-stage workshops, and a Funded Ticket Scheme. - A community show inspired by Wings working with adults experiencing dementia or neurological disorders. This will be performed at the Young Vic, in care homes and medical centres.

Amount: £50,000
Funder: The Wellcome Trust
Recipient: Young Vic Company

Madame Geneva: A tale of gin & prostitution 31 Mar 2017

Macha Productions seeks to stage Madame Geneva, a bawdy song and dance, set in 18th Century London where performance, baroque, folk, contemporary music, professional and community actors all meet over a bottle of gin. Madame Geneva, the popular name for gin, lands with the Dutch armies of William of Orange, almost immediately invoking a gloriously decadent atmosphere across the classes. Sold at the corner-shop she offers the poor, particularly women, easy-access to alcohol. The Government struggles to find a way to reap rewards from gin taxes whilst trying to alienate lower classes from imbibing. To this end, Madame Geneva’s gin-addled image is tied to fallen women, fishwives and bad mothers, in turn this influences the establishment of the Magdalen Penitentiary, where approaches to the reform of fallen women institutionalize narratives of good and bad women. These moral narratives often underpin current approaches to women, poverty, addiction, public health and social policy. Working with trainee-actor participants from some of Northern Irelands most deprived communities and Dr Anne Campbell, Macha productions professional team will premiere Madame Geneva at Lyric Theatre, Belfast, to provoke awareness, debate and media coverage on the rising tide of addiction that rampages through Northern Ireland’s post-conflict society.

Amount: £19,000
Funder: The Wellcome Trust
Recipient: MACHA Productions

The Rowntree Archives: Poverty, Philanthropy and the Birth of Social Science 18 May 2017

The project will arrange, describe, publicise and make publicly available the archives of the Rowntree Trusts and the Rowntree family for the first time. The outputs: open key 20th century archives on public health in the UK, including research about health problems caused by or related to alcohol, unemployment, housing, old age, and betting and gambling; open for research key records documenting the theory and practice of relationships between employers, philanthropy, social justice and public health; provide materials for researching the birth and early development of social science in the UK; will establish regular transfers of records from the Trusts to the Borthwick, thereby securing for public use records yet to be created. We will do this by creating fully searchable online finding aids to international standards, with authority files and access points mediated by current experts in the field, and links to related archives in York and elsewhere. The project’s success measures are: the production of publicly accessible online catalogues; the creation of research projects based on the archives; securing a sustainable future for the archives, including future archives.

Amount: £114,930
Funder: The Wellcome Trust
Recipient: University of York

Unlocking the Asylum: North Wales Hospital Archive 1848-1995 18 May 2017

The project aims to encourage research in the historic archive of the North Wales Hospital. The objectives are to catalogue, list and package the archive, to promote it as an important academic resource and to explain the Hospital’s history to the wider public. The hospital was the main institution in North Wales for the care of the mentally ill for almost 150 years, opening in October 1848 and closing in 1995. The completion of the project will see: An itemised catalogue of the existing accessions re-catalogued to current standards. An itemised catalogue of later accessions of administration records. The later accession of patient case files will be listed and repackaged. The collection will be assessed for conservation needs and preventive preservation measures highlighted and put in place. The collection will be assessed for potential digitisation projects/digital resources. Our target audiences are those involved in historical research, both from a higher education and a leisure perspective. The project will make the North Wales Hospital collection accessible to the wider community, providing an invaluable resource to academia whilst making the publicly available material more accessible to the non-academic general user.

Amount: £129,993
Funder: The Wellcome Trust
Recipient: Denbighshire County Council

Spinal to Sport: The pioneering work of Sir Ludwig Guttmann 25 Nov 2016

This project covers all aspects of work at Stoke Mandeville Spinal Injuries Unit - from the impact of Sir Ludwig Guttmann's ideas on the rehabilitation of paraplegics to the development of national and international games for the disabled, and their enormous expansion from humble beginnings to the Paralympic Games of today. The different records included in this project offer a detailed insight into the development of treatments for patients with spinal injuries, their care and rehabilitation. As NSIC patients tend to be looked after for life, their patient case files provide a longitudinal study of people living with spinal injuries. The growth of disabled sports was rapid and it created a range of bodies. Stoke Mandeville was at the centre of this whirlpool and the records show how different rules and regulations brought about the elite competition of today. The records have been moved several times and are in disarray, with some damage to some records. To enable these rich resorces to be made available to researchers, sorting, cataloguing and conservation is essential. Due to the size and storage of the collections, it is necessary for CBS to find external grant funding to enable us to carry out the work.

Amount: £175,566
Funder: The Wellcome Trust
Recipient: Buckinghamshire County Council

Putting Flesh on the Bones: cataloguing and digitising the Calvin Wells Archive 25 Nov 2016

Calvin Wells (CW) is regarded to be the founding father of palaeopathology in the UK. His archive comprises books, offprints, notebooks, correspondence, poems, photographs, negatives, slides, radiographs, microfilms and videocassettes relating to the medical humanities in general and palaeopathology specifically. The data within the archive pertains to archaeological human remains, many of which have now been reburied or lost. Access to primary data, notes and images will allow researchers to reassess CW’s work, while the broader archive offers insights into his fascinating life. On his death in 1978 CW’s archive was curated by his widow, Freddie Wells, and deposited with the University of Bradford. On arrival, the archive was split between the University library and the palaeopathology laboratory (then named the Calvin Wells Laboratory, now the Biological Anthropology Research Centre) and became intermixed with other paperwork and images in the lab. This project aims to disentangle the lab archive and true CW Archive, reunite the two halves of the CW archive, fully catalogue and conserve the material held and digitise images for preservation. The final archive will be deposited with Special Collections, JB Priestley Library, University of Bradford, allowing researchers to access and interrogate it easily.

Amount: £137,517
Funder: The Wellcome Trust
Recipient: University of Bradford

Conserving and opening up access to the Foundling Hospital medical records 25 Nov 2016

The Foundling Hospital was the first dedicated children’s charity in the UK and has a rich history spanning over 275 years recorded in a large archive touching the lives of 25,000 children. The medical records of the Hospital provide a detailed and complete account of the health and medical treatment of the children from the 18th to the 20th centuries. The records are already catalogued online; however, their poor physical condition means that much is too fragile to be produced to researchers fro consultation. The aim of the project is to ensure the long term preservation of the records by repairing the fragile and damaged items, repackaging them in conservation-grade materials. Digitisation and making the records available online will further assure their long-term future by providing digital surrogates whilst at the same time facilitating and extending access for researchers. The records will be promoted to the academic community and public through an engagement programme developed in collaboration with academics working in children’s health and other relevant fields, institutions holding related material, the Foundling Hospital’s successor Coram, and the Foundling Museum. Research themes will be built into LMA’s schools and outreach programmes including an exhibition in its dedicated display space.

Amount: £58,533
Funder: The Wellcome Trust
Recipient: London Metropolitan Archives

Colonial Consumption: Alcohol, Medicine & Society in British India 18 May 2017

This project engages with the role of alcohol in colonial British India c. 1800-1947. It analyses the extent to which alcohol was embedded in medical, social and cultural discourses of colonial society, producing a range of conflicted and contradictory practices. Using archives such as the British Library and the National Library of Scotland, the project will focus on how alcohol remained a mainstay of colonial medicine, military routine, and Anglo-Indian culture throughout the British presence in South Asia, despite concerns over health. The project has three key goals. Firstly, to focus on the inconsistency with which drinking and intoxication were either criminalised or mitigated by medical expertise; by contrasting records relating to India and Britain, I will argue that colonial space itself was a dominant determining factor in decisions made by military and civil authorities whether to treat or punish excessive drinking. Secondly, to accumulate data that will enable academic and public-facing outputs related to the drinking cultures of colonial British society and British military forces during the C. 19th. Finally, this project will act as preparation for a Wellcome Seed Award application designed to compare and contrast attitudes to alcohol across the wider British Empire during the same period.

Amount: £23,884
Funder: The Wellcome Trust
Recipient: Bournemouth University

Tackling Histoplasmosis; a neglected disease impacting on equine health and human livelihoods. 25 May 2017

Histoplasmosis is a neglected yet prevalent disease among working equids in sub-Saharan Africa where horses provide a critical source of income and draught power for transport and agriculture to millions of people. There is a lack of evidence for the mechanisms of transmission and persistence of histoplasmosis offering little rationale upon which to base disease control. This novel multidisciplinary study will combine epidemiological, ecological and community engagement approaches to investigate the dynamics of this endemic disease, and will be achieved through an international collaboration across the academic, veterinary and NGO sectors. Phase 1 comprises a prospective multi-centre cohort study, a nested case-control study, and a clinical case-series. Clinical and environmental samples will be collected along with epidemiological data to determine the contribution of environment and host factors to both susceptibility and response to the disease. Clinical samples will be analysed using serological and molecular biological techniques to determine the presence and state of infection and to characterise Histoplasma diversity. Single-cell genome sequencing will be used to define predominant and/or virulent strains. Phase 2 will involve consultation with the community and regional stakeholders to share research findings and develop and disseminate disease prevention advice facilitated by the NGO partners.

Amount: £30,000
Funder: The Wellcome Trust
Recipient: Brooke Hospital for Animals

Intestinal epithelial cells: at the interface of the microbiota and mucosal immunity 22 Feb 2017

Intestinal infections affect billions of people worldwide, resulting in nearly 1.4 million deaths each year. The commensal microbiota can prevent pathogenic infection, as demonstrated by increased susceptibility to infection upon antibiotic use; however, the precise mechanisms of microbiota-mediated protection are not well-characterized. I have recently discovered that colonization of mice with commensal Enterococcus faecium leads to improved intestinal barrier function and decreased Salmonella and Clostridium difficile pathogenesis. I went on to uncover a mechanism by which a unique enzyme, SagA, from these bacteria activates intestinal epithelial cells (IECs) to increase anti-microbial peptide (AMP) expression and mucin distribution. These studies revealed several host and microbiota factors involved in pathogen tolerance. My proposed independent research will identify the mechanisms by which commensal bacteria modulate IECs and intestinal immunity. Utilizing advance microscopy, proteomics and sequencing approaches, I will characterize the effects of E. faecium, SagA and other microbiota metabolites on IEC gene expression and function and subsequent pathogen resistance. Using proteomics-based bioorthogonal reporters and intersectional genetics, I will then dissect how microbial modulation of IECs affects the differentiation and function of intraepithelial lymphocytes. Elucidating the IEC programs triggered by commensal bacteria will enable better strategies to prevent and treat intestinal infections.

Amount: £13,200
Funder: The Wellcome Trust
Recipient: Wellcome Trust Sanger Institute

Partnering for Equitable STEM Pathways for Youth from Minoritized Communities. 07 Nov 2016

Minoritized Youth, addresses fundamental equity issues in informal STEM learning (SL+ priority D, Equity, diversity and access to informal learning settings). The major goal of our Partnership is for practitioners and researchers, working with minoritized youth, to develop new understandings of how and under what conditions minoritized youth participate in Informal STEM Learning (ISL) over time and across settings, and how they may connect these experiences towards pathways into STEM. We will: 1) Develop new understandings of ISL pathways that are equitable and transformative for minoritized youth; 2) Co-develop high leverage practices and tools that support these equitable and transformative ISL pathways (and the agency youth need to path-make); and 3) Strengthen and increase professional capacity to broaden participation among youth from minoritized communities in STEM through ISL. Our work is grounded in longitudinal youth participatory ethnographies, surveys, and design-based implementation research methodologies. Our major goal responds to three challenges at the intersections of ISL research and practice in the US/UK: 1) lack of shared understanding of how minoritized youth perceive and experience ISL opportunities across the US/UK, and the practices and tools needed to support empowered movement through ISL; 2) limited shared understanding and evidence of core high-leverage practices that support minoritized youth in progressing within and across ISL, and 3) limited understanding of how ISL might be equitable and transformative for minoritized youth seeking to develop their own pathways into STEM. We focus on minoritized youth, ages 11-14, for whom there are wide and persistent gaps in representation in STEM, and for whom STEM careers and pursuits remain elusive. The project will be carried out by RPPs in 4 cities: London & Bristol, UK and Lansing, MI & Portland, OR, US, involving university researchers (Kings College, University College London, Michigan State University, Oregon State University) practitioners in science museums (@Bristol Science Centre, Brent Lodge Park Animal Centre, Impressions 5, OMSI) and community-based centers (STEMettes, Knowle West Media Centre, Boys & Girls Clubs of Lansing, and Girls, Inc.).

Amount: £621,873
Funder: The Wellcome Trust
Recipient: University College London

Embodied Learning for Preschool Scientists (Move2Learn). 07 Nov 2016

Move2Learn (M2L), a Science Learning+ research proposal, addresses the priority area of understanding learning through rigorous study of how preschool children (ages 3-5), especially those from underserved communities, use their bodies to learn, communicate, and feel about STEM. M2L considers the proposition that bodily movement is tightly intertwined with thinking, a theoretical notion captured by the phrase ’embodied cognition.’ Building on decades of empirical research as well as a Phase I SL+ planning grant, M2L pursues translational research that brings research findings from the lab to the museum floor with the aim to strengthen the impact of informal learning exhibitions on young learners and their families. The project will advance the development of a new research model in which practitioner/researcher teams jointly will (1) develop, test and refine new instrumentation to capture impact and artifacts of embodied learning (gestures, actions, movement) in informal contexts, and (2) conduct a series of studies in six strategically chosen sites across the US and UK to leverage the knowledge and experience of science and children museum professionals who have extensive experience working with children and families from a wide range of socioeconomic, cultural, and ethnic backgrounds. The collaboration is essential to maximize the robustness and reproducibility of research findings on an international scale.

Amount: £582,375
Funder: The Wellcome Trust
Recipient: University of Edinburgh

A Pilot Study of Contemporary Notions of Sexuality and Sexual Health in Post-Colonial South Africa 24 May 2017

In this pilot study, we seek to investigate the ways in which people experience, frame, and perceive sexuality in post-colonial South Africa and how these impact the success or uptake of sexual health interventions. In particular, we will develop an inter-institutional collaboration between anthropologists, a biomedical researcher, and an artist to examine how people mediate between public discourse, received information from institutional authorities, and lived dimensions of personal sexual activity. Key goals include combining the strengths of anthropological research with the strategies of a youth-focused public engagement project to investigate contemporary notions of sexuality and sexual health interventions with a cohort of previously disadvantaged youth in Johannesburg. Drawing on diverse networks of the PI and collaborators, we will also host an interdisciplinary symposium as a way to develop a robust network of local sexual health researchers, facilitate dialogue with government, media, and civil society stakeholders, and identify future potential collaborators. Project outputs will provide a strong foundation for pursuing future research grants to develop a formal, longitudinal, inter-generational study of perceptions around sexual health, which will enable insight into how interactions between such perceptions across categories of difference influence the conception, implementation, and outcomes of national sexual health policy.

Amount: £57,969
Funder: The Wellcome Trust
Recipient: University of the Witwatersrand

Pharmacosexuality: the past, present and future of sex on drugs 24 May 2017

What is the relationship between the pharmaceuticalisation of sexuality, health promotion, and recreational drug use in sexual contexts? How might this relationship change current paradigms of sexual health? The use of illicit drugs in sexual contexts and its implications for public health is receiving closer attention from the media, health practitioners and communities than ever before. However, current research remains focused on men who have sex with men (MSM) populations involved in 'chemsex', viewed predominantly through the lenses of risk and harm reduction, with little attention paid to the experimental and pleasurable dimensions of sex on drugs, its interaction with the growth of phamaceutical interventions for sex, or its broader history in cultural and clinical contexts. Through archival and empirical scoping, this project will develop a socially, historically and culturally informed approach to drug/sex repertoires, termed 'pharmacosexuality', with the following goals: 1. To identify key themes and research questions, which will underpin major grant applications, including a Wellcome Collaborative Award. 2. To bring together scholars and practitioners for a new interdisciplinary network in 'pharmacosexuality'. 3. To produce two peer-reviewed publications, which will break new ground by contextualising 'pharmacosexuality' historically, and exploring how 'synthetic aphrodisiacs' are used in sexual contexts contemporarily.

Amount: £34,041
Funder: The Wellcome Trust
Recipient: Royal Holloway, University of London

Normative female sexuality and abortion stigma: a feasibility study using qualitative secondary analysis 24 May 2017

This project examines the relationship between female sexuality and the stigmatisation of abortion, directly addressing femininity, marginalisation and sexual/health rights. Worldwide, abortion remains controversial, and highly stigmatised, as it challenges powerful social norms of feminine sexuality, particularly in socio-cultural contexts where women’s moral autonomy is contested. A growing body of US-focused scholarship demonstrates that stigma, underpinned by health inequalities, creates barriers for women seeking essential healthcare, and contributes to the medical and social marginalisation of abortion. However, little is known about processes through which narratives of ‘deviant’ female sexuality contribute towards abortion stigma in the UK. We will test the feasibility of using qualitative secondary analysis of existing datasets, to synthesise knowledge of manifestations of abortion stigma in different UK jurisdictions. This approach, undertaken by an interdisciplinary team with significant expertise in abortion research and provision, will explore the interface between feminine sexuality and abortion in the narratives of women, providers, educators, and wider society. The study is timely given the potential impact of ongoing political change on abortion provision. This preparatory/scoping work is essential in establishing the feasibility of a larger collaborative proposal that will incorporate additional datasets, and utilise this foundation to develop a stigma-reduction intervention.

Amount: £69,507
Funder: The Wellcome Trust
Recipient: University of Glasgow

Out on the Pitch: Sexuality and Mental Health in Men's and Women's Sport, 1970-Present 24 May 2017

Why have more women athletes come out than men? What role has sport played in facilitating or preventing LGBT athletes from coming out and what effect has this had (both positive and negative) on mental health? ‘Out on the Pitch’ is a scoping project for a future Wellcome Trust Collaborative Award application focussing on Sport and Mental Health, and involving Matthew Smith, Mark Doidge and Ali Haggett. This future bid will be framed on three research strands: Sport as Therapy; Narratives of Sport and Mental Health; and Sport as a Challenge to Mental Health. As our plans for the Collaborative Award progressed, sexuality became an increasingly important theme - spanning all three of our research strands - but was also the one we felt we needed the most development, planning and support to research. Objectives: Test methods for recruiting and interviewing athletes about this emotive and, sadly, still controversial topic Bring together academics, athletes and activists to inform our approach to research and knowledge exchange Consult archives to assess their importance to the future project Construct a database of sport autobiographies that deal with sexuality Explore publish engagement possibilities, including filming a documentary

Amount: £75,271
Funder: The Wellcome Trust
Recipient: University of Strathclyde