- Total grants
- Total funders
- Total recipients
- Earliest award date
- 05 Jan 2016
- Latest award date
- 22 Dec 2016
- Total GBP grants
- Total GBP awarded
- Largest GBP award
- Smallest GBP award
- Total Non-GBP grants
Developing and applying big data analyses to checkpoint performance.
Wellcome Centre for Integrative Neuroimaging 30 Oct 2016
Understanding how interactions between neurons generate human behaviour, why individual brains vary from one another, or whether a patient is likely to develop a particular disease, requires explanations that span vast differences in scale. Yet such explanations are essential if insights from neuroscience are to make a meaningful impact on human health. Precise mechanisms discovered in animal models must be related to clinical phenotypes discovered through population studies; both must be combined to improve diagnosis and treatment in individual patients. Neuroimaging offers a powerful route to connect these different scales, providing measurements that are sensitive to cellular phenomena and that can be acquired in living humans. The WT Centre for Integrative Neuroimaging will enable novel insights into brain function that span levels of description, and therefore bridge the gap between laboratory neuroscience and human health. This will require fundamental discoveries concerning relationships between species and between scales, and major technological developments for mapping big-data discoveries onto neurobiological mechanisms. We will bring together diverse investigators who can tackle different themes within this grand challenge. Within each theme, neuroimaging will be used alongside complementary methodologies, ensuring that it takes inspiration from, and has impact on, areas beyond its typical reach.
Health and economic benefits of water-sensitive revitalisation in informal urban settlements 06 Oct 2016
Urbanisation is a major demographic trend globally. Informal settlements account for much urban growth, exacerbating the inextricably linked challenges of sanitation, water provision, and public health. The conventional ‘big pipes’ solution to these challenges has changed little in 150 years, comes at major financial, environmental, and social costs, and frequently overlooks informal settlements. We have pioneered an alternative, water-sensitive approach that integrates sustainable design with the management of the water-cycle, benefiting human health and urban ecosystems. This decentralised, climate-change sensitive approach provides financial flexibility for multistage developments and adaptability to future technologies. It promises a solution to the water services challenges of informal settlements, yet has only been demonstrated in developed world settings. We will examine whether the water-sensitive approach can be applied to revitalise developing-world informal settlements to improve environmental and public health outcomes. Our evidence-based assessment of its efficacy across 24 settlements, poorly served by water infrastructure in Makassar and Suva, will deliver the first public health and environmental data on the benefits and risks of water-sensitive approaches. Our scientific, economic and implementation findings will provide the basis for profound changes to infrastructure policies, investments, loan strategies, and their sustainability across the Asia-Pacific and the developing world.
Deep evolutionary history of bacterial pathogens 05 Jul 2016
How old are bacterial pathogens, and what evolutionary steps have they undergone? Comparative genomics can accurately resolve recent demography and genealogy of bacterial pathogens. Some historical pathogenic lineages have also been reconstructed by taking advantage of ancient genomes (aDNA), including the causes of plague, cholera, tuberculosis and leprosy. Although ground-breaking, these lineages were relatively easy to analyse using conventional tools due to limited genetic diversity and little recombination, and prior studies on existing genomic diversity. Generating a historical framework for most bacterial pathogens that currently threaten human health, and our food supply, is much more challenging because historical records do not provide unambiguous bacterial identification. Furthermore, the long-term population structure and genealogies of most bacteria are not well defined due to high levels of genetic diversity and frequent recombination, including Salmonella enterica. We will reconstruct the long-term evolutionary history of bacterial pathogens using both metagenomic data from ancient samples and population genetic data from present-day bacteria. We will use the latest developments in aDNA sequencing, develop new bioinformatic approaches for metagenomic analyses, and create a big-data overview of modern genetic diversity. This strategy will be implemented for S. enterica, and then applied to other pathogens.
The emergence of bacteria that can resist antibiotics is a major health emergency. Many advances in medicine, including organ transplantation, increased survival of pre-term infants, cancer chemotherapy and surgery are dependent on antibiotics that prevent or treat infection. Antibiotics work by targeting processes that bacteria use but humans cells do not. For example, penicillin stops bacteria making cell walls, which human cells do not have. This means that penicillin can attack bacterial cells but not human cells. Unfortunately, when bacteria become resistant these bacterial processes can no longer be targeted. The aim of this project is to use antibiotic resistance itself as a target for a new type of antibiotic. One of the most important types of resistance involves a bacterial enzyme that cuts up penicillin and similar antibiotics, and stops them from working. Dr Andrew Edwards and colleagues from Imperial College London will design new antibiotics that look similar to penicillin. However, when the enzyme cuts these antibiotics they will become lethal to the bacteria. In addition to killing resistant bacteria, the project team believe that this approach will also reduce damage to the good bacteria in the body, which are often harmed by conventional antibiotics.
MetaboFlow - the development of standardised workflows for processing metabolomics data to aid reproducible data sharing and big data initiatives 16 Jun 2016
The processing and analysis of mass spectrometry and nuclear magnetic resonance spectroscopy data in metabolomics is largely performed on an individual basis following local laboratory methodologies. Metabolomics lacks reproducible computational workflows based on internationally accepted standard operating procedures and this is impacting on the field in terms of reproducibility of studies and subsequent sharing of data. Furthermore, with improvements in reproducibility in analytical equipment, individual laboratories are acquiring larger, more complex datasets, which are a significant challenge to process. We propose to build, test and deliver the cloud-based Galaxy workflow, MetaboFlow, which will have computational capacity to process datasets with 1000s of samples and simultaneously capture all metadata associated with the users’ data processing workflow to allow rigorous reproducibility. We will formulate the workflow using several popular processing, feature extraction and compound identification tools and provide functionality to readily use on-line databases including our international repository, MetaboLights. The tools will be selected based on our current survey of the international metabolomics community. This proposal is a re-submission following consultation with the Trust. Specifically we have developed and implemented a plan to capture the communities’ needs, and have made significant cost savings by integrating our work with other initiatives using Galaxy.
Arts & Craft Activities 27 May 2016
We would like to get arts and crafts namely paints, brushes, paper, paint pots, sponges etc. etc. playdough, glue, card, bits and bobs to do collage i..e feathers, pom poms, glitter, sequins. Different things to do throughout the year to cover mothers day, fathers day, Easter, halloween and Christmas. Refreshments for year (i.e. tea, coffee, milk, sugar, fruit, biscuits, mugs, beakers, juice, water etc. etc. toilet rolls, black bags, cleaning materials. Replace some outdated babies items namely, highchairs, walkers, bouncy chairs. Staff costs to enable the employment of an individual Part payment for rent costs = £6 a day = £28 a week. The difference this grant would make to our group would be stability for a year to cover all aspects that need to be paid for. Really hope we are successful s this group is so worthwhile for Wood Farm Estate which is a very deprived estate in Oxford.
Rochdale Cares to Act 01 Jun 2016
This is the development and continuation of a project that aims to deliver support to vulnerable children and young people living in and around Rochdale. The group will provide more creative workshops, courses, mentoring and group drop-in sessions to help the beneficiaries with team building, life skills, confidence and self-esteem. Parental support programmes will also be available to help families build better relationships.
Seated Swing 06 Sep 2016
This organisation will run a programme of seated dance class therapy workshops for older people in care homes and day centres in Edinburgh. The funding will cover sessional staff costs and evaluation costs.
This is the expansion of a project supporting people with learning disabilities in East Hertfordshire, Welwyn Hatfield, Broxbourne and Hertsmere to overcome loneliness and social isolation. Leisure and social activities will help people gain new friends and experiences, and improve skills and confidence to live more independently. There will also be workshops on issues like relationships, communication and employment. The funding will allow the group to expand reach to Three Rivers, Watford and West Essex.
Learning Senses 19 Dec 2016
The funding will be used by a primary school to create an outdoor area for creative and sensory play. The project aims enhance the outdoor environment and provide children with the opportunity to develop their social interaction skills confidence.
Juniors and Inters Youth Clubs 19 Dec 2016
The project will establish a junior youth club for 8-11 year olds and an inters youth club for 11-13 year olds and deliver sport taster and healthy eating sessions. This will provide a safe environment for children and young people to develop social skills, confidence and self-esteem and improve their opportunities and wellbeing.
The charity works with lesbian and bisexual (LB) women and their families. They are using the Â£10,000 for a series of activities to improve the emotional and wellbeing needs of older lesbian and bisexual women.
Celebrating Harrows Diversity 25 Aug 2016
A week long programme that celebrates Harrowâ€™s rich history and diversity. It will bring people of all cultures, religions, ethnic backgrounds and age groups together during the February half term holidays in 2017. The programme will include performances, a theatre tour, an opportunity for people to make their own CD in the recording studio, a show for young children, a 40â€™s war time dancing session and community stalls.
Frenford Accessible IT Project 29 Jun 2016
The group will use the funding to replace IT hardware. This will help build capacity and enable wider community usage. Beneficiaries will include individuals experiencing deprivation,living with the effects of physical disabilities or learning difficulties
Raidio Failte Teo - celebrating 10 years 16 Dec 2016
The organisation provides a radio service through the medium of Irish language to 40,000 Irish speakers and learners in the Belfast area. They are using the grant to celebrate 10 years of community broadcasting to local people.
Outings for Pensioners 29 Nov 2016
Killay and District Lunch Club in Swansea will use the grant to provide two day trips to places of interest for up to 40 members at risk of social isolation. This grant for Â£1,580 will fund transport, meals, and a steam train ride.