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The Wellcome Trust
Award Year:


IVerbal Autopsy with Participatory Action Research (VAPAR): expanding the knowledge base through partnerships for action on health equity 26 Oct 2016

<p>Health systems are increasingly considered in terms beyond 'building blocks' models, as complex, adaptive, human and relational. Despite the conceptual advances, people-centered health systems research methods remain underdeveloped. The proposed work will connect two issues: the lack of information on the health of people excluded from access to health systems, and the low utilisation of research evidence by health systems stakeholders. The proposal is to institutionalise a process to strengthen data on mortality registration, combine with local knowledge, and interpret, plan and act on this basis in the health system at different levels. The method combines Verbal Autopsy (VA) with Participatory Action Research (PAR). VA is a method to determine levels, causes and circumstances of deaths. In PAR, communities organise evidence for action. 3 phases are proposed. In Phase 1, a series of 3 reflection and action cycles will be conducted to generate evidence, analyse, plan and act. Data will be generated on levels, causes and circumstances of deaths (using VA) and on health needs and priorities for action (using PAR) with communities. Data will be analysed with provincial level policy makers, action plans will be developed and implemented by district-level practitioners, and progress will be re-assessed in subsequent cycles. In Phase 2, participants and researchers will evaluate the process using realist and political economy methods to understand changes in care, outcomes and progress towards health equity. In Phase 3, sustainability and transferability will be developed with authorities, research and technical groups, health systems stakeholders and communities in the study site, and to the public. The output will be a process based on international standards, that is contextually relevant in health systems at different levels, and capable of translating local priorities into actionable agendas for health systems strengthening as a means towards health equity.</p>

Amount: £235,156
Funder: The Wellcome Trust
Recipient: University of Aberdeen

Impact of Rapid Expansion of the Estratégia de Saúde da Familia in Rio de Janeiro: Mixed Methods Evaluation 26 Oct 2016

<p>Our project aims to influence the development of PHC in Rio de Janeiro, other large cities in Brazil, and internationally by generating and actively disseminating timely evidence to policy-makers&nbsp; especially in a period of economical crisis. We will achieve this by including policy-makers and programme implementers from Rio de Janeiro in our research team. We will jointly host dissemination events with the Pan American Health Association in Rio de Janeiro and Brasilia with policy makers from cities across Brazil to share the findings in order to inform policy development in the country and internationally. Our evaluation will provide important information to other countries seeking to achieve UHC in major urban areas and large cities, such as Colombia and India. By fostering links between academics and policy makers from Brazil, UK, and USA with extensive experience in analysing linked datasets, microsimulation modelling and qualitative research, we will build research skills and research translation capacity among all team members.</p>

Amount: £159,936
Funder: The Wellcome Trust
Recipient: Imperial College London

WT-MRC Clinical Research Training Fellowship Partnership 30 Nov 2016

<p>Wellcome funding will allow the MRC to appoint an extra 5 CRTFs between 2017-2021.&nbsp;</p>

Amount: £6,325,000
Funder: The Wellcome Trust
Recipient: Medical Research Council

British Library for Development Studies scoping project 31 Dec 2016

<p>This application is for a scoping study of the historic collection of the British Library for Development Studies.</p> <p>The Library is based in the Institute of Development Studies, at the University of Sussex.&nbsp; This unique and valuable collection of print material was developed over the period between 1966, when the Institute of Development Studies was established, and 2016.&nbsp; There are approximately one million volumes including: 80,000 monographs and 10,000 serial titles.&nbsp; Taken all together this is the largest social science collection focused on development studies in Europe.</p> <p>Given the ongoing global shift to digital information, a new model of library provision is being developed to support IDS.&nbsp; The historic print collection needs to be protected, and the Institute is keen to find ways to exploit the potential of the collection for all researchers.&nbsp; There are particular challenges associated with the size and complexity of the collection, the use of a local classification scheme, and gaps in the coverage of the catalogue.</p> <p>The proposed scoping study is intended to create a comprehensive description and analysis of the collection. &nbsp;This will act as an invaluable framework for further work to make material more visible and accessible to as many researchers as possible.</p>

Amount: £7,500
Funder: The Wellcome Trust
Recipient: Institute of Development Studies

Scoping of the archive held by the Museum of the Order of St John 31 Dec 2016

<p>&nbsp;&nbsp;&nbsp; The Museum of the Order of St John needs to better understand the content of the archive and its conservation needs, in order to make this resource accessible and to raise the profile of this valuable body of&nbsp;information. &nbsp;The Museum requests a grant for&nbsp;a&nbsp;scoping project which&nbsp;will result in a report detailing its archival holdings, will help to&nbsp;clarify the steps required to realise the archive&rsquo;s research potential and will enable the Museum&nbsp;team to explore ways in which to make this archive more accessible.&nbsp; It is our intention to go on to apply for the Research Resources grant, supported by the findings of the scoping project, in order to fully catalogue and conserve the archive so that we may encourage and facilitate research visits, and better respond to research enquiries.</p> <p>&nbsp;&nbsp;&nbsp; The report will also be a valuable tool in seeking advocacy and support for improved standards and greater aspirations for the archive within the wider organisation.&nbsp; An informed professional opinion will articulate a more compelling argument for the value of this project and will encourage the continuing support of key stakeholders.</p>

Amount: £8,850
Funder: The Wellcome Trust
Recipient: St John Ambulance (UK)

The Peckham Experiment: Fiction from the Archives 15 Nov 2016

<p>Over the course of 5 months, I propose to research the archive of the Pioneer Health Centre, held at the Wellcome Library, and write a series of prose poems, fictions and creative-critical texts based on the materials in the archive. The project builds on my existing research and writing around this archive, allowing me to realistically propose several substantial goals within a relatively compressed timeframe. I aim to:</p> <ul> <li>Produce a significant body of prose texts to be published in part in literary journals and as a collection by a respected press in the emerging genre of experimental or hybrid creative-critical prose.</li> <li>Explore through these texts ideas from the archive with contemporary relevance, such as the relationship between the individual and the collective, or between self-organisation and experimentation.</li> <li>Advance the practice of creative-critical writing and further the argument that creative writing can produce new insights into a topic.</li> <li>Develop a new audience for archival writing, the Peckham Experiment archives and the Wellcome Library&rsquo;s collections via my publications, discussions with peers and a day-long public engagement workshop.</li> </ul>

Amount: £25,000
Funder: The Wellcome Trust
Recipient: No Organisation

Enhancing the catalogue of the scientific papers of Professor Alexander Haddow, 1912-1978 31 Dec 2016

<p>Objectives: This cataloguing and preservation project will open up the research possibilities of the papers of Alexander John Haddow (1912-1978), entomological epidemiologist and key member of the investigative team who originally discovered the Zika virus.</p> <p>Details of work: The Project Archivist will improve access to the collection by providing an item-level on-line catalogue. This will allow users to discover the collections full research potential, not only of Haddow&rsquo;s Zika virus research data, but also the data relating to many other mosquito-borne viruses found within the collection, including the Chikungunya virus.&nbsp; Primarily this will involve enhancing descriptions of the research data by indexing the viruses, vectors and data collection techniques used by Haddow and his colleagues. This will make them easily discoverable online to inexperienced users of archive collections like many in the scientific research community. To promote the collection&rsquo;s long-term preservation, it will be repackaged in acid-free folders and boxes, and ferrous clips and staples will be replaced with brass paperclips. A detailed condition assessment of each item will be undertaken during cataloguing, and a preservation plan will be agreed with the Preservation manager. Taken together these two strands of work will prepare the collection for a future digitisation project.</p>

Amount: £9,371
Funder: The Wellcome Trust
Recipient: University of Glasgow

Science Learning+ STEM Teens: Examining the role of youth educators as learners and teachers in informal STEM learning sites. 07 Nov 2016

<p>This proposal is for a Science Learning+ Partnership Grant to examine STEM (Science, Technology, Engineering and Math) engagement outcomes for youth educators and the visitors with whom they interact in informal STEM learning sites (ISLS). The proposed research targets the following priority areas: A) Understanding learning: we will examine how experiences as youth educators in ISLS provide opportunities for adolescents to increase their STEM knowledge as well as how they provide informal STEM education to visitors to these centers; B) STEM Engagement: we will longitudinally track youth educators&rsquo; STEM interest, engagement, stereotypes and motivation, educational aspirations, course-taking and eventual choice of major or profession; C) Equity, diversity and access to informal learning settings: we will examine underrepresented minority youth educator and visitor evaluations of their experiences and inclusion in ISLS and visitor engagement after interacting with youth educators; D) Measurement of outcomes: we will measure outcomes related to educational achievement and STEM interest and engagement using quantitative and qualitative methods to forward knowledge of how to assess informal STEM learning. The goal of the proposed research is to examine outcomes of youth educator experiences related to STEM identity, educational aspirations and motivation of the youth educators as well as to identify outcomes that the youth educators have on the visitors to ISLS in terms of knowledge, interest and engagement in STEM, and to evaluate how these relate to participant demographics and across different informal educational environments. The specific aims are: 1) Outcomes for Teens - To measure the longitudinal impact of participation in an extended youth educator experience in an ISLS; 2) Outcomes for Visitors - To compare visitor engagement with and learning from exhibits in ISLS when they interact with a youth educator, relative to outcomes of interacting with an adult educator or no educator; and 3) Outcomes Across Demographics and STEM Sites - To examine differences in visitor engagement based on participant characteristics such as SES, age, gender, and ethnicity and to compare outcomes of youth educator experiences across different types of ISLS as represented by: The Riverbanks Zoo and Garden (US), The Virginia Aquarium and Marine Science Center (US), EdVenture Children&rsquo;s Museum (US), the Florence Nightingale Museum (UK), the ThinkTank (UK), and Centre of the Cell (UK).</p>

Amount: £755,679
Funder: The Wellcome Trust
Recipient: Goldsmiths, University of London

Partnering for Equitable STEM Pathways for Youth from Minoritized Communities. 07 Nov 2016

<p>Minoritized Youth, addresses fundamental equity issues in informal STEM learning (SL+ priority D, Equity, diversity and access to informal learning settings). The major goal of our Partnership is for practitioners and researchers, working with minoritized youth, to develop new understandings of how and under what conditions minoritized youth participate in Informal STEM Learning (ISL) over time and across settings, and how they may connect these experiences towards pathways into STEM. We will: 1) Develop new understandings of ISL pathways that are equitable and transformative for minoritized youth; 2) Co-develop high leverage practices and tools that support these equitable and transformative ISL pathways (and the agency youth need to path-make); and 3) Strengthen and increase professional capacity to broaden participation among youth from minoritized communities in STEM through ISL. Our work is grounded in longitudinal youth participatory ethnographies, surveys, and design-based implementation research methodologies.&nbsp; Our major goal responds to three challenges at the intersections of ISL research and practice in the US/UK: 1) lack of shared understanding of how minoritized youth perceive and experience ISL opportunities across the US/UK, and the practices and tools needed to support empowered movement through ISL; 2) limited shared understanding and evidence of core high-leverage practices that support minoritized youth in progressing within and across ISL, and 3) limited understanding of how ISL might be equitable and transformative for minoritized youth seeking to develop their own pathways into STEM. We focus on minoritized youth, ages 11-14, for whom there are wide and persistent gaps in representation in STEM, and for whom STEM careers and pursuits remain elusive.&nbsp; The project will be carried out by RPPs in 4 cities: London &amp; Bristol, UK and Lansing, MI &amp; Portland, OR, US, involving university researchers (Kings College, University College London, Michigan State University, Oregon State University) practitioners in science museums (@Bristol Science Centre, Brent Lodge Park Animal Centre, Impressions 5, OMSI) and community-based centers (STEMettes, Knowle West Media Centre, Boys &amp; Girls Clubs of Lansing, and Girls, Inc.).</p>

Amount: £749,245
Funder: The Wellcome Trust
Recipient: University College London

Embodied Learning for Preschool Scientists (Move2Learn). 07 Nov 2016

<p>Move2Learn (M2L), a Science Learning+ research proposal, addresses the priority area of understanding learning through rigorous study of how preschool children (ages 3-5), especially those from underserved communities, use their bodies to learn, communicate, and feel about STEM. M2L considers the proposition that bodily movement is tightly intertwined with thinking, a theoretical notion captured by the phrase &rsquo;embodied cognition.&rsquo; Building on decades of empirical research as well as a Phase I SL+ planning grant, M2L pursues translational research that brings research findings from the lab to the museum floor with the aim to strengthen the impact of informal learning exhibitions on young learners and their families. &nbsp;The project will advance the development of a new research model in which practitioner/researcher teams jointly will (1) develop, test and refine new instrumentation to capture impact and artifacts of embodied learning (gestures, actions, movement) in informal contexts, and (2) conduct a series of studies in six strategically chosen sites across the US and UK to leverage the knowledge and experience of science and children museum professionals who have extensive experience working with children and families from a wide range of socioeconomic, cultural, and ethnic backgrounds. The collaboration is essential to maximize the robustness and reproducibility of research findings on an international scale.</p>

Amount: £701,656
Funder: The Wellcome Trust
Recipient: University of Edinburgh

Creativity and Equity in STEM Learning. 07 Nov 2016

<p>The University of Washington and Science Gallery Dublin, in partnership with several US and UK organizations, propose a Science Learning+ Phase 2 project: Creativity and Equity in STEM Learning. The project aims to drive and transform a next generation of broadening participation efforts targeting teen-aged youth from communities historically underrepresented in STEM fields (hereinafter "under-represented youth"). The project investigates how out-of-school time (OST) programs, integrating epistemic practices of both the arts and sciences, in the context of consequential activities (such as creating radio segments, museum exhibitions, or online games for the general public), can more broadly appeal to and engage youth who do not already identify as STEM learners. This project builds on a Wellcome Trust SL+ Phase 1 award (105948/Z/14/Z).</p>

Amount: £775,353
Funder: The Wellcome Trust
Recipient: Trinity College Dublin

Science Learning +: Examining learning processes through the integration of two informal science learning approaches: Natural History Museum-led citizen science. 07 Nov 2016

<p>Science Learning +: Examining learning processes through the integration of two informal science learning approaches: Natural History Museum-led citizen science. We focus our proposed practice-based, mixed-methods research on the priority areas of 1) understanding learning and 2) engagement in STEM by systematically examining the ways youth (ages 5-19 years) participate in authentic environmental science research, as facilitated by Natural History Museums (NHMs) in the US and the UK (NHM London, California Academy of Sciences, NHM Los Angeles County). Through integration of two approaches to informal science education i) natural history museums and ii) citizen science (CS), we examine three learning settings (event-based, longer-term outdoor monitoring, and online settings). Our goal is to address the overarching question: How do authentic science experiences such as NHM-led citizen science foster or support key practices of Environmental Science Agency (ESA)? Youth ESA includes: a) understanding the environmental science discipline&rsquo;s content and norms, b) identifying one&rsquo;s own expertise within the that discipline, and c) using the environmental science and CS project as a foundation for change in their own community. Through international collaboration between experts from diverse disciplines, environmental science, citizen science, museum practice, environmental education, learning analytics and technologies for pedagogy, this work will inform, and be informed by, science learning practice in both countries. Over four years we will: 1) explore and characterize youth participation in different learning environments, 2) examine learning outcomes across settings from a socio-cultural learning theory perspective, and 3) identify strategies that programs can implement to enhance learning outcomes. This proposal builds on years of our collaboration studying NHM-led citizen science (e.g.Ballard et al. in press), and PI Ballard (Univ. of CA, Davis) and Co-I Herodotou's (Open University) years of research on the learning outcomes of youth-focused citizen science. The NHMs, with their dual focus on science research and environmental education, established CS programs, close ties with local urban community-based organizations, and partnerships with large online CS platforms (Zooniverse and iNaturalist), provide a unique route through which we can examine how youth participation in authentic science may build their capacity and agency for science.</p>

Amount: £684,032
Funder: The Wellcome Trust
Recipient: Natural History Museum

Spinal to Sport: The pioneering work of Sir Ludwig Guttmann 25 Nov 2016

<p>This&nbsp;project covers all aspects of work at Stoke Mandeville Spinal Injuries Unit&nbsp;- from the impact of Sir Ludwig Guttmann's ideas on the rehabilitation of paraplegics to&nbsp;the development of national and international games for&nbsp;the disabled, and their enormous expansion from humble beginnings to the Paralympic Games of today.</p> <p>The different&nbsp;records included in this project offer a detailed insight into the development of treatments for patients with spinal injuries, their care and rehabilitation.&nbsp; As NSIC patients tend to be looked after for life, their patient case files provide a longitudinal study of&nbsp;people living with spinal injuries.</p> <p>The growth of disabled sports was rapid and it created a range of bodies.&nbsp; Stoke Mandeville was at the centre of this whirlpool and the records show how different rules and regulations&nbsp;brought about the elite competition&nbsp;of today.</p> <p>The records have been moved several times and are in disarray, with some damage&nbsp;to some records.&nbsp; To enable these rich resorces to be made available to researchers, sorting, cataloguing and conservation&nbsp;is essential.&nbsp; Due to the size and storage of the collections, it is necessary for CBS to find external grant funding to enable us to&nbsp;carry out the work.</p>

Amount: £175,566
Funder: The Wellcome Trust
Recipient: Buckinghamshire County Council

Expanding the capabilities and use of the South West Regional Facility for High-Resolution Electron Cryo-microscopy 07 Dec 2016

<p>State-of-the-art direct electron detectors (DEDs) and new image processing strategies enable electron cryo-microscopy (cryoEM) routinely to achieve near-atomic resolution of biological samples. CryoEM has thus become a primary imaging technique, increasing the need for research institutions to provide cutting-edge cryoEM equipment. The Living Systems Institute (LSI) at the University of Exeter is a brand new interdisciplinary research centre, which will develop strategies to study diseases and their prevention. As part of the GW4 group (also including Bristol, Bath and Cardiff), we seek to develop regional research infrastructure on a scale beyond the capabilities of the single institutions. Within this remit, the Wellcome Trust-funded <strong>South West Regional Facility for High-Resolution Electron Cryo-microscopy</strong> will be established in Bristol, with a 200kV cutting-edge cryo electron microscope at its core. To support this venture and significantly increase the capabilities of the facility for all users within GW4, we plan to contribute a state-of-the art K3 DED with energy-filter. We also plan to establish an entry-level multiuser cryoEM facility at the LSI, supporting the research needs of local users in order to provide samples for further high-resolution analysis in Bristol and at the Wellcome Trust-funded <strong>electron Bio-Imaging Centre</strong> (<strong>eBIC</strong>) at Diamond.</p>

Amount: £1,000,000
Funder: The Wellcome Trust
Recipient: University of Exeter