- Total grants
- Total funders
- Total recipients
- Earliest award date
- 15 Apr 2008
- Latest award date
- 16 Sep 2008
- Total GBP grants
- Total GBP awarded
- Largest GBP award
- Smallest GBP award
- Total Non-GBP grants
The aim of this project is to define C. difficile genes and gene products essential for adherence to host tissues. The objectives are: 1. To establish a robust model of adhesion of C. difficile to the cultured enteric CaCo2 cell line. 2. To further study adhesion using in vitro organ cultures of hamster gut. 3. To create knock-out mutants of defined genes in C. difficile and to analyse their behaviour in the adhesion models of the bacterium with host tissues. Genes and gene products identified as important for adhesion will be further studied using molecular and biochemical techniques.
History of Medicine Resarch Student Conference to be held at the Wellcome Trust Centre for the History of Medicine at UCL from 19-20 June 2008. 27 May 2008
History of Medicine Research Student Conference
The project is collaboration with Prof. Vivian Nutton to examine the philosophical and astrological background of the pseudo-Galenic De Spermate (existing in Latin translation, dated to the thirteen and fourteen centuries). Our specific goals are to evaluate the philosophical and astrological background of the treatise and in particular its Neoplatonic influence; to establish possible Neoplatonic sources; to examine the dialogue between medicine, philosophy, and astrology in the treatise; to assess the attitude toward astrology in the treatise in the context of the traditional antithetical relationship between medicine and astrology and philosophy in Late Antiquity.
The history of monastic bloodletting as revealed in medieval monastic account rolls and visitation records 16 Sep 2008
The main purpose of this trip is to carry out research necessary to complete a monograph on the function of periodic bloodletting in medieval monastic life. I will be looking primarily at account rolls from monasteries and cathedral abbeys in order to determine the actual dates on which religious were bled. This is important because preliminary investigations indicate that the bleeding sometimes coincided with days deemed perilous in medical tests; I need to learn whether my initial findings are representative or anomalous. Examining the days when religious were bled may also be one way of determining changes in the practice over time; in addition, it may shed light on differences in bleeding practices between religious orders. Bloodletting appears not only in account rolls; it is also a subject mentioned in many episcopal visitation records and in the General Chapter statutes of the Cistercian and Carthusian orders. This research will provide an opportunity to examine those records more closely to determine concerns associated with the time of bloodletting. The complaints may help to reveal more about the perceived importance of regular bloodletting, its perceived function, as well as anxieties about potential lapses in discipline during the period of convalescence.
The 1918 influenza pandemic represents the worst outbreak of infectious disease in Britain in modern times. Although the virus swept the world in three waves between March 1918 and April 1919, in Britain the majority of the estimated 228,000 fatalities occurred in the autumn of 1918. In London alone deaths at the peak of the epidemic were 55.5 per 1,000- the highest since the 1849 cholera epidemic. Yet in the capital as in other great cities and towns throughout Britain, there was none of the panic that had accompanied earlier 19th century outbreaks of infectious disease at the heart of urban populations. Instead, the British response to the 'Spanish Lady' as the pandemic strain of flu was familiarly known was remarkably sanguine. As The Times commented at the height of the pandemic: 'Never since the Black Death has such a plague swept over the face of the world, [and] never, perhaps, has a plague been more stoically accepted.' The apparent absence of marked social responses to the 1918 influenza is a phenomenon much remarked on in the literature of the pandemic, as is the apparent paradox that despite the widespread morbidity and high mortality the pandemic had little apparent impact on public institutions and left few traces in public memory. However, to date no one has explored the deeper cultural 'narratives' that informed and conditioned these responses. Was Britain really a more stoical and robust nation in 1918, or was the absence of medical and other social responses a reflection of the particular social and political conditions that prevailed in Britain during the First World War and then medical nosologies and cultural perceptions of influenza? And if the 1918 pandemic was 'overshadowed,' as one writer puts it, by the war and the peace that followed the Armistice, what explains the similarly muted response to the Russian flu pandemic of the early 1890's, a disease outbreak that coincided with a long period of peace and stability in Britain? In this project I aim to show that, contrary to previous studies, both the 1918 and the 1889-92 Russian flu pandemic were the objects of much deeper public concern and anxiety than has previously been acknowledged and that the morbidity of prominent members of British society, coupled with the high mortality, occasioned widespread 'dread' and in some cases alarm. However, in 1918 at least, government departments and public institutions actively suppressed these concerns for the sake of the war effort and the maintenance of national morale.
The World Health Organization and the social determinants of health: assessing theory, policy and practice (an international conference). 29 Aug 2008
The World Health Oraganisation and the Social Determinants of Health: Assessing theory, policy and practice (An international conference).