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Funders:
The Wellcome Trust
Recipients:
University of Edinburgh
Amounts:
£500 - £1,000

Results

Quarantine and typhus in the writing of Elizabeth Gaskell. 25 Mar 2013

This grant is requested to cover travel, subsistence, and photocopying costs for two research trips to the Wellcome Library. I will spend two weeks in February and one week in March 2013 conducting research into (i) nineteenth-century quarantine legislation and procedures in Britain (ii) nineteenth-century typhus epidemics, their association with military campaigns and the Irish famine, and William Jenner's differentiation of typhus and typhoid in 1850. There will be two research outputs: (i) an essay on quarantine and typhus in Elizabeth Gaskell's 1853 novel 'Ruth' to be published in the forthcoming edited collection 'Place, Progress, and Personhood in the Works of Elizabeth Gaskell', edited by Emily Morris, Sarina Gruver Moore, and Lesa Scholl; (ii) a conference presentation on quarantine, mobility and typhus epidemics in Gaskell's writing at the joint conference of the North American Victorian Studies Association, the British Association of Victorian Studies, and the Australasian Vi ctorian Studies Association in June 2013. I am also proposing a paper based on this research for the Association for Medical Humanities conference in July 2013, for which the conference theme is Global Medical Humanities.

Amount: £552
Funder: The Wellcome Trust
Recipient: University of Edinburgh

Protein-protein and protein-ligand interactions in the glycolytic pathway. 20 May 2011

T. brucei is a small parasite that causes African trypanisomiasis, commonly known as sleeping sickness, in humans and nagana in cattle in Africa. It has life cycle stages in both the mammalian host and the tsetse fly vector and makes several morphological and biochemical changes when migrating between the two. The mechanisms and control of cell proliferation and differentiation is essential to the life cycle of the parasite and thus understanding the details of these processes is important for the discovery of new drug targets to combat this disease. The genome of T. brucei and other related parasites have been sequenced and many biochemical and genetic tools are available to enable molecular dissection of the genes involved in cell division and differentiation. Previous studies of the structural mechanics of cell division have provided us with some understanding of the temporal and spatial organisation of the cell organelle and cytoskeletal structures [1]. However, much more needs to be understood about the three-dimensional spatial organisation of the cytoskeletal structures and how co-ordination of assembly and cytokinesis is performed in order to better understand the phenotypes presented by the molecular dissection experiments. During my 10 week project I used scanning electron microscopy (SEM), transmission electron microscopy (TEM), immunofluorescence microscopy, and video microscopy to gain more insight into cytoskeletal organisation during cell division, and to compare the processes in the procyclic and the bloodstream forms of the parasite. SEM and video microscopy revealed important differences between the procyclic and bloodstream forms during cell division regarding attachment and growth of the new flagellum, the degree of staggering of the daughter cells during cleavage furrow ingression and the nature of the cytoplasmic connection between the two daughter cells, present just before cell abscission. Fluorescent labelling of ?-tubulin and TEM images provided some evidence for the presence of microtubules in the cytoplasmic connection in the procyclic form, although more evidence is needed.

Amount: £585
Funder: The Wellcome Trust
Recipient: University of Edinburgh