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Grant to Homeless Action Resource Project 27 Mar 2020

to support homeless people in Southend during the COVID19 crisis

Grant to Maldon & District Community Voluntary Services 27 Mar 2020

to support community response helping people during the COVID19 pandemic in rural districts of Maldon

Grant to Harlow Citizens Advice Bureau 27 Mar 2020

To supply additional IT equipment to staff and volunteers to ensure they can respond to an increased demand to the COVID19 pandemic

Grant to Mind in West Essex 27 Mar 2020

to provide a response and recovery grant during the COVID19 crisis to an organisation supporting those with mental health issues in West Essex

Amount: £12,212
Funder: Essex Community Foundation
Recipient: Mind in West Essex

Grant to Chelmsford Community Transport Ltd 27 Mar 2020

to provide a shopping service for older people and a transport service for those with health conditions receiving vital treatment at Broomfield Hospital during the COVID19 pandemic

To support disabled people's organisations response to the coronavirus. 30 Mar 2020

To support disabled people's organisations response to the coronavirus pandemic.

Amount: £81,000
Funder: Three Guineas Trust
Recipient: Inclusion London
Region: London
District: Lambeth London Boro

To the Coronavirus Appeal for regranting to small charities and grassroots 30 Mar 2020

To the London Communities Coronavirus Appeal for regranting to small charities and grassroots organisations across the capital.

Amount: £250,000
Funder: Three Guineas Trust
Recipient: London Community Foundation
Region: London
District: Lambeth London Boro

Supporting their Coronavirus appeal 19 Mar 2020

Unrestricted core funding.

Amount: £1,000,000
Funder: Indigo Trust
Recipient: National Emergencies Trust
Region: London
District: City and County of the City of London

Grant to Halstead Day Centre 27 Mar 2020

to help sustain a Centre dedicated to providing care for elderly people in Halstead and its rural surroundings during the COVID 19 crisis

Amount: £15,000
Funder: Essex Community Foundation
Recipient: Halstead Day Centre

Grant to The Social Investment Business Group 19 Mar 2020

Towards project costs for building an insight tool for needs analysis of communities during the covid-9 pandemic.

Ribosomal frameshifting and readthrough in virus gene expression. 24 May 2010

This project will focus on the role of recoding in the replication of the model retroviruses Rous sarcoma virus (RSV; frameshifting) and murine leukemia virus (MuLV; readthrough) and the coronavirus murine hepatitis virus (MHV, frameshifting). Specific mutations will be introduced into the recoding signals such that individual viruses, over a broad range, exhibit a defined frameshifting or readthrough efficiency. The replication of these engineered viruses will be assessed and their tolerance to changes in efficiency determined. As an alternative approach, recoding efficiency will be modulated using small molecules, including antibiotics known to affect recoding, and by targeting the stimulatory RNA structures with oligonucleotides. The mechanism of the readthrough process will also be investigated. Unlike frameshifting, we know little about how the stimulatory RNA pseudoknot of MuLV perturbs ribosome function. This will be investigated by biochemical analysis of ribosome-pseudoknot co mplexes, using primer-extension/toeprinting, RNA secondary structure probing and cryo-electron microscopy (cryo-EM).Overall, this project aims to establish the extent to which recoding can be modified before virus replication is compromised, to determine whether recoding is a valid target for antiviral intervention and to clarify the mechanism of readthrough, which may identify new approaches to antiviral therapy.

Amount: £250,000
Funder: The Wellcome Trust
Recipient: University of Cambridge

The epidemiology of MERS-CoV within the dromedary camel population, and zoonotic transmission to humans. 30 Sep 2018

Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a virus with pandemic potential. It can cause severe respiratory disease in humans, and was first isolated in 2012 in Saudi Arabia. Since then, more than 2079 human cases of MERS and 722 deaths have been reported to the World Health Organisation (WHO), mainly by Saudi Arabia. Evidence shows that the virus can be transmitted to humans from dromedary camels, and can also be spread from human-to-human in settings where people have close contact such as in hospitals. Surveys find that a high proportion of camels in the Arabian Peninsula and countries in North Africa have antibodies against MERS-CoV, indicating that many have been infected with the virus, which itself has been isolated from camels. However, incidence of reported human MERS cases varies hugely over this region. This work will use WHO case data to investigate the risk factors associated with higher numbers of camel-to-human transmissions of MERS-CoV, which are currently unclear making it hard to design interventions against MERS. We also aim to use mathematical models of MERS transmission amongst camels, and genetic analysis of the viruses isolated from camels to better characterise the way the virus circulates in the animals.

Amount: £0
Funder: The Wellcome Trust
Recipient: Imperial College London