- Total grants
- Total funders
- Total recipients
- Earliest award date
- 24 May 2010
- Latest award date
- 30 Mar 2020
- Total GBP grants
- Total GBP awarded
- Largest GBP award
- Smallest GBP award
- Total Non-GBP grants
to support community response helping people during the COVID19 pandemic in rural districts of Maldon
Grant to Chelmsford Community Transport Ltd 27 Mar 2020
to provide a shopping service for older people and a transport service for those with health conditions receiving vital treatment at Broomfield Hospital during the COVID19 pandemic
To support disabled people's organisations response to the coronavirus pandemic.
To the London Communities Coronavirus Appeal for regranting to small charities and grassroots organisations across the capital.
Grant to The Social Investment Business Group 19 Mar 2020
Towards project costs for building an insight tool for needs analysis of communities during the covid-9 pandemic.
This project will focus on the role of recoding in the replication of the model retroviruses Rous sarcoma virus (RSV; frameshifting) and murine leukemia virus (MuLV; readthrough) and the coronavirus murine hepatitis virus (MHV, frameshifting). Specific mutations will be introduced into the recoding signals such that individual viruses, over a broad range, exhibit a defined frameshifting or readthrough efficiency. The replication of these engineered viruses will be assessed and their tolerance to changes in efficiency determined. As an alternative approach, recoding efficiency will be modulated using small molecules, including antibiotics known to affect recoding, and by targeting the stimulatory RNA structures with oligonucleotides. The mechanism of the readthrough process will also be investigated. Unlike frameshifting, we know little about how the stimulatory RNA pseudoknot of MuLV perturbs ribosome function. This will be investigated by biochemical analysis of ribosome-pseudoknot co mplexes, using primer-extension/toeprinting, RNA secondary structure probing and cryo-electron microscopy (cryo-EM).Overall, this project aims to establish the extent to which recoding can be modified before virus replication is compromised, to determine whether recoding is a valid target for antiviral intervention and to clarify the mechanism of readthrough, which may identify new approaches to antiviral therapy.
The epidemiology of MERS-CoV within the dromedary camel population, and zoonotic transmission to humans. 30 Sep 2018
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a virus with pandemic potential. It can cause severe respiratory disease in humans, and was first isolated in 2012 in Saudi Arabia. Since then, more than 2079 human cases of MERS and 722 deaths have been reported to the World Health Organisation (WHO), mainly by Saudi Arabia. Evidence shows that the virus can be transmitted to humans from dromedary camels, and can also be spread from human-to-human in settings where people have close contact such as in hospitals. Surveys find that a high proportion of camels in the Arabian Peninsula and countries in North Africa have antibodies against MERS-CoV, indicating that many have been infected with the virus, which itself has been isolated from camels. However, incidence of reported human MERS cases varies hugely over this region. This work will use WHO case data to investigate the risk factors associated with higher numbers of camel-to-human transmissions of MERS-CoV, which are currently unclear making it hard to design interventions against MERS. We also aim to use mathematical models of MERS transmission amongst camels, and genetic analysis of the viruses isolated from camels to better characterise the way the virus circulates in the animals.