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Results

The genetic architecture of cardiovascular structural phenotypes in cardiac remodelling 29 Jun 2016

Cardiovascular structural phenotypes and their adverse remodelling exert a powerful prognostic impact on cardiovascular diseases. It leads to heart failure, which creates a major healthcare and economic burden in the world. Cardiovascular structural variations result from a complex interplay between genes and environmental factors. Although the environmental influence is well established, little is known about the genetic factors. UK Biobank is a prospective population study, which provides magnetic resonance imaging-derived cardiovascular phenotypes and genetic data, enabling the implementation of large-scale genome-wide association studies. The primary aims of this fellowship are to investigate the heritability of cardiovascular structures and to identify genetic markers of cardiac remodelling using left ventricular (LV) phenotypes (Nmax = 55,000) and right ventricular, atrial, aortic and other novel phenotypes such as LV trabeculation and native myocardial T1 value (Nmax = 5,000). This project will enhance our understanding of the genetic architecture of cardiac remodelling processes, and the knowledge gained will have the potential to improve risk stratification and identify new therapeutic targets. Key words: cardiovascular structures, cardiovascular remodelling, magnetic resonance imaging, heritability, genome-wide association studies

Biophysical and structural characterisation of an in vitro-assembled viral DNApackaging system 24 Jun 2013

During the assembly of herpes viruses a DNA packaging motor inserts the viral genome into procapsids. Related motors from tailed bacteriophages have proved to be excellent models for understanding this process. Thus, we propose to assemble in vitro the motor system of Escherichia coli phage HK97 for further biophysical and structural studies. Single-molecule magnetic tweezers experiments will be conducted to explore the kinetics and thermodynamics of packaging as well as the requirements for a functional system. Electron microscopy and Xray crystallography will be used to determine structures of the assembly intermediates and of individual components and sub-complexes. Ultimately, we hope to elucidate the mechanisms of viral DNA packaging so that we are better informed when studying more complicated systems such as herpes viruses.

Amount: £149,673
Funder: The Wellcome Trust
Recipient: University of York

Grant to Cymdeithas Cadwraeth Llanrhaeadr YC Preservation Society 19 Jun 2014

St Dyfnog's Well and Surrounding Environs Conservation Project

Writing for All 13 Nov 2006

The project is to establish a new group supporting creative writing skills. The money is for speakers' fees, workshop costs, training, equipment and publicity materials.

Amount: £4,395
Funder: The Big Lottery Fund
Recipient: Writers of Denbighshire
Region: Wales
District: Sir Ddinbych - Denbighshire

Writing For all 13 Nov 2006

The project is to establish a new group supporting creative writing skills. The money is for speakers' fees, workshop costs, training, equipment and publicity materials.

Amount: £3,616
Funder: The Big Lottery Fund
Recipient: Writers Next Door
Region: Wales
District: Sir Ddinbych - Denbighshire

Christchurch Community Primary School - MUGA and gymnasium 11 May 2004

Denbighshire County Council will build a floodlit Multi Use Games Area (MUGA) and modernise a gymnasium and changing rooms at Christchurch Community Primary School. The aims of the project include increasing extra curricular opportunities, increasing women and girls participation, increasing the range of activities and addressing social inclusion. The project will help deliver athletics, dance, gymnastics, judo, football and netball. The main beneficiaries of the project will be 1,018 pupils at 8 schools.

Amount: £241,448
Funder: The Big Lottery Fund
Recipient: Denbighshire County Council
Region: Wales
District: Sir Ddinbych - Denbighshire

There is no project name available for this record 02 Nov 2005

The project will provide a Community transport scheme for the isolated rural areas of Peniel, Prion, Nantglyn and Saron in Denbighshire The three year grant will pay for vehicle purchase, running costs, training for volunteers and CRB checks_x000B__x000B_Bydd y prosiect yn darparu cynllun trafnidiaeth cymunedol ar gyfer ardaloedd gwledig anghysbell Peniel, Prion, Nantglyn a Saron yn Sir Ddinbych.

Amount: £39,577
Funder: The Big Lottery Fund
Recipient: Cart y Plwyf Association
Region: Wales
District: Sir Ddinbych - Denbighshire

Unspecified 23 Aug 2005

The project is to develop the group's digital photography activities. The money is for a laptop computer, projector and photographic software.

Amount: £4,987
Funder: The Big Lottery Fund
Recipient: Ruthin Camera Club
Region: Wales
District: Sir Ddinbych - Denbighshire

Safety at the show 21 Jan 2008

The project is to extend the facilities of the group. The money is for sheep and cattle pens.

Nwyddau I Merched Y Wawr 23 Apr 2007

The project will improve the facilities of the group. The money is for crockery, tables and chairs.

Refurbishment of Wi House, 67 Vale Street Denbigh 13 Feb 2009

The project is to refurbish a training centre for women. The money is for materials and labour.

Hiraethog Fair 10 Mar 2010

Cymdeithas Hiraethog Association will hold a community event which will bring people together to take part in activities and learn how they can have fun, get fit and enjoy themselves at low or no cost and appreciate the natural environment of the area. This grant for £4,099 will fund workshop costs, hire of climbing wall, trampolines and mini bus, event insurance and publicity costs.

Speech, Launguage and Communication, Information, Sharing of Good Practice 02 Sep 2009

Afasic will fund an exhibition event in Llandudno, which will demonstrate the sharing of good practice across North Wales for children and young people with speech and language impairment. The project meets the Awards for All aims of improving the quality of life and extending access and participation.The grant for £5,000 will part fund the venue hire, participatory events and volunteer expenses.

Amount: £5,000
Funder: The Big Lottery Fund
Recipient: Afasic
Region: Wales
District: Sir Ddinbych - Denbighshire

Prosiect Rhanbarth Glyn Maelor Eisteddfod Genedlaethol Wrecsam 2011 28 Apr 2011

Merched y Wawr Rhanbarth Glyn Maelor will set up a tent full of activities in the Eisteddfod 2011 for Welsh speakers and learners in the hope of attracting new members and giving their volunteers the opportunity to use the Welsh language in a social setting. The grant for £5,000 will fund half of the hire of the tent, refreshments, some volunteer admissions costs, children's activities, equipment transport costs, presentation costs, Welsh learner activities, floral exhibit and a laptop

New Stage for Pant Pastynog 16 Dec 2016

Ysgol Pant Pastynog in Denbigh will use the grant to improve the facilities available to the pupils at the school and the rural local community. This grant for £5,000 will part-fund 24 piece portable staging.

Amount: £5,000
Funder: The Big Lottery Fund
Recipient: Ysgol Pant Pastynog
Region: Wales
District: Sir Ddinbych - Denbighshire

Caban y Plwyf 23 May 2013

Caban y Plwyf will provide a new community facility for the use of current community run groups in the local area. This project meets the Awards for All aim of 'supporting community activity'. The grant for £5,000 will fund a contribution to towards the renovation costs of a wood cabin.

Amount: £5,000
Funder: The Big Lottery Fund
Recipient: Caban y Plwyf
Region: Wales
District: Sir Ddinbych - Denbighshire

Dyfrdwy Gwerin y Coed new groups, camping and volunteer development 25 Apr 2013

Dyfrdwy Gwerin y Coed will establish two new Woodcraft Fold groups in Denbigh and Llangollen, providing fun and educational outdoor activities for children. This meets the Awards for All aim of 'extending access and participation'. This grant for £4,999 will fund training, camping costs, camping equipment, craft materials, travel and set-up costs.

Amount: £4,999
Funder: The Big Lottery Fund
Recipient: Dyfrdwy Gwerin y Coed
Region: Wales
District: Sir Ddinbych - Denbighshire

King Georges Playing Field Improvements 21 Jun 2015

King Georges Playing Field Improvements

Amount: £5,000
Funder: The Big Lottery Fund
Recipient: King George's Field
Region: Wales
District: Sir Ddinbych - Denbighshire

Young Vic ‘Intro To’ Series 2019 15 Mar 2019

Young Vic ‘Intro To’ Series 2019

Amount: £19,950
Funder: Walcot Foundation
Recipient: Young Vic
Region: London
District: Lambeth London Boro

CTCTYP Capacity Building Project 17 Jul 2006

Employment of a new Outreach Worker post to enable the initiation and development of the youth theatre's first ever outreach programme covering Wrexham, Denbighshire and Flintshire.

Amount: £28,260
Funder: Paul Hamlyn Foundation
Recipient: Clwyd Theatr Cymru
Region: Wales
District: Sir y Fflint - Flintshire