Optimisation and testing of high affinity, selective, phosphate binding materials with biomedical applications (360G-Wellcome-074426_Z_04_A)
Excess phosphate anions build up in the blood of patients with end-stage renal failure, leading to the condition hyperphosphatemia, a condition which, if untreated, can lead to serious side effects - in some cases fatal. In previous studies, we have developed high affinity phosphate receptors which operate in biologically relevant conditions. This proposal targets the continued development of these high affinity phosphate binders, and aims to convert them into phosphate binding polymers. We will then illustrate the relevance of these materials for the treatment of hyperphosphatemia using a series of in vitro and in vivo studies. In this new proposal we intend to: Develop useful crosslinked polymeric materials with high phosphate affinity - different phosphate binding monomers, crosslinkers and co-monomers will be used in order to generate a range of materials, Determine the ability of the different polymers developed above to bind phosphate under biologically relevant conditions (in vitro) - simple phosphate uptake experiments and assays will be performed. To use the results from parts 1 and 2 to further optimize the phosphate binding polymeric materials. To test the final optimized phosphate binding polymers in vivo. The effect of the polymers on phosphate uptake will be monitored in healthy rats in order to find the best candidate for therapeutic use. This candidate polymer will then be tested in nephrectomised rats, which are a useful model system for patients with kidney failure. This study will lead to therapeutically useful phosphate binding polymers, and sufficient data will have been generated that commercialisation of these materials will be a serious possibility. Commercial development will occur either by setting up a spin-off company, or by licensing the technology to one of the companies currently active in developing this type of therapy
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Grant Details
Amount Awarded | 49993 |
Applicant Surname | Smith |
Approval Committee | Technology Transfer Challenge Committee |
Award Date | 2008-01-16T00:00:00+00:00 |
Financial Year | 2007/08 |
Grant Programme: Title | Translation Award |
Internal ID | 074426/Z/04/A |
Lead Applicant | Dr David Smith |
Other Applicant(s) | Dr Bart Nelissen |
Partnership Value | 49993 |
Planned Dates: End Date | 2008-05-30T00:00:00+00:00 |
Planned Dates: Start Date | 2008-01-31T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Yorkshire and the Humber |