CD40 and CD154: breaking and maintaining peripheral tolerance to pancreatic beta cells. (360G-Wellcome-075452_Z_04_A)

£7,584

CD40 and CD154: Breaking and maintaining peripheral tolerance to pancreatic beta cells 1. To determine the regulatory capacity of CD40-induced CD4+CD25+ T cells and the role of CD40 in their expansion. 2. To determine the point of divergence between the CD40 and TNFa signalling pathways and how this leads to distinct cellular outcomes. 3. To determine the role of TNFa in the prevention of CD40-induced expansion of CD4+CD25+ T cells.

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Grant Details

Amount Awarded 7584
Applicant Surname Spence
Approval Committee Immunology and Infectious Disease Funding Committee
Award Date 2006-02-08T00:00:00+00:00
Financial Year 2005/06
Grant Programme: Title PhD Studentship (Basic)
Internal ID 075452/Z/04/A
Lead Applicant Dr Philip Spence
Partnership Value 7584
Planned Dates: End Date 2008-09-30T00:00:00+00:00
Planned Dates: Start Date 2005-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England
Sponsor(s) Prof Douglas Fearon