The role of two G protein-coupled receptors in regulating appetite and energy expenditure. (360G-Wellcome-075777_Z_04_A)

£54,000

The process of feeding is a relatively automated process, with feed-forward and feedback sensory information from the whole orogastrointestinal tract driving reflex loops and central pattern generators in the brainstem, so that once a meal is started we continue to eat until we reach satiety. While these direct regulators of feeding control the size of an individual meal, this information has to integrate with the indirect regulators of feeding that include metabolic, nutritional, behavioural, rhythmic and social factors. We have postulated a role for two peptides expressed in the brainstem, prolactin-releasing peptide and neuromedin U, to link the direct and indirect regulators of feeding, since they both have profound effects on appetite and energy expenditure. However, due to the lack of antagonists for these peptides, it has been difficult to provide definitive proof of our theory. We now have available two transgenic mouse lines that are deficient in receptors for these peptides, and at least one of these lines has an obese phenotype. Using the mice, and with complementary studies in rats, we will test how the two peptides affect appetite and energy expenditure, and how they impinge on other systems controlling behaviour and circadian rhythms.

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Grant Details

Amount Awarded 54000
Applicant Surname Luckman
Approval Committee Physiological Sciences Funding Committee
Award Date 2006-06-12T00:00:00+00:00
Financial Year 2005/06
Grant Programme: Title Project Grant
Internal ID 075777/Z/04/A
Lead Applicant Prof Simon Luckman
Partnership Value 54000
Planned Dates: End Date 2008-03-31T00:00:00+00:00
Planned Dates: Start Date 2005-04-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region North West