Control of chromosome segregation during meiosis. (360G-Wellcome-076605_Z_05_A)

£30,028

During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation. Homologous chromosomes are segregated during meiosis I, whereas sister chromatids are segregated during meiosis II, which resembles mitosis in many aspects. This requires several modifications to the segregation machinery, including the way cohesion between sister chromatids is regulated. During mitosis, sister chromatid cohesion is lost simultaneously along the entire length of chromosomes, which triggers the onset of sister chromatid separation. However, in meiosis, sister chromatid cohesion is lost in a step-wise manner. Loss of cohesion on chromosome arms in meiosis I abolishes the linkage between homologues and allows them to segregate. Cohesion between sister chromatids is, however, maintained around the centromeric regions to keep them together until meiosis II. I propose to elucidate the mechanism that protects cohesion around the centromere during meiosis I, using budding yeast as a model system. I intend to identify and characterize the proteins that prevent loss of centromeric cohesion during meiosis I (protector proteins). I will then investigate the mode of action of protector proteins by analyzing their interactions with each other and with the factors that generate cohesion (cohesins). Finally, I will determine how protector proteins are themselves regulated.

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Grant Details

Amount Awarded 30028
Applicant Surname Marston
Approval Committee Molecules, Genes and Cells Funding Committee
Award Date 2006-03-28T00:00:00+00:00
Financial Year 2005/06
Grant Programme: Title Research Career Development Fellowship
Internal ID 076605/Z/05/A
Lead Applicant Prof Adele Marston
Partnership Value 30028
Planned Dates: End Date 2011-02-28T00:00:00+00:00
Planned Dates: Start Date 2006-03-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Scotland