Use of unique animal models to study reversible effects of hyperglycaemia on the arterial edothelium in vivo. (360G-Wellcome-077683_Z_05_Z)

£177,335

Despite many noteworthy achievements in management, most individuals with diabetes will still die early largely as a result of arterial diseases and heart attacks. In fact, likelihood of developing coronary disease rises by 300% or more if you develop diabetes and is more likely to prove fatal. Surprisingly, given that high blood glucose levels are the 'hallmark' feature of diabetes, we still do not fully understand how glucose itself might damage the arteries and cause heart attacks. In order to understand heart artery diseases in diabetes we must disentangle the effects of glucose from those of high blood fats, blood pressure etc. Since this is not currently possible in man we will use uniquely appropriate mouse models to answer the following critical questions:a) Does high glucose change the proteins being made in the artery wall or the types of cells that are present and over what time?b) Can these changes go back to normal if we set the glucose level back to normal?c) Do the above changes effect the development of fatty deposits that cause heartattacks? Understanding these processes will greatly increase our understandingof coronary diseases in diabetes and might help identify new targets for future drug development.

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Grant Details

Amount Awarded 177335
Applicant Surname Khan
Approval Committee Physiological Sciences Funding Committee
Award Date 2005-11-07T00:00:00+00:00
Financial Year 2005/06
Grant Programme: Title Project Grant
Internal ID 077683/Z/05/Z
Lead Applicant Dr Michael Khan
Other Applicant(s) Prof David Epstein
Partnership Value 177335
Planned Dates: End Date 2009-01-31T00:00:00+00:00
Planned Dates: Start Date 2006-02-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region West Midlands