BMP2/4 signalling in T cell development. (360G-Wellcome-077995_Z_05_Z)
The thymus, the primary site of T cell production, is seeded throughout life by blood borne lymphocyte progenitor cells from the foetal liver or adult bone marrow. This project aims to test the hypothesis that the Bone Morphogenetic Protein (BMP) 2 and 4 signalling pathway is an important regulator of haematopoiesis and thymopoiesis. The BMP family of secreted intercellular signalling molecules are powerful regulators of patterning and organogenesis of many mammalian tissues during embryonic development, but relatively little is known about the function of BMP signalling in the immune system. To avoid complications of redundancy and promiscuity between components of the signalling pathway, we will focus on the type I BMP Receptors for BMP2 and BMP4: BMPR1A and BMPR1B. We will use conditional BMPR1A knock-out mice to study the function of BMP signalling in haematopoietic stem cells and lymphocyte progenitor cells and developing thymocytes. As BMPR1B-/- are viable, we will use these animals to investigate the function of BMPR1B in lymphocyte progenitor cells and developing T cells. Key goals: (1) To define the functions of BMP2/4 signalling in thymocyte development(2) To elucidate molecular mechanisms that underlie these functions(3) To identify target genes that are transcriptionally regulated by the pathway.
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Grant Details
Amount Awarded | 302561 |
Applicant Surname | Crompton |
Approval Committee | Immunology and Infectious Disease Funding Committee |
Award Date | 2005-10-25T00:00:00+00:00 |
Financial Year | 2005/06 |
Grant Programme: Title | Project Grant |
Internal ID | 077995/Z/05/Z |
Lead Applicant | Prof Tessa Crompton |
Partnership Value | 302561 |
Planned Dates: End Date | 2010-03-31T00:00:00+00:00 |
Planned Dates: Start Date | 2006-03-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |