BMP2/4 signalling in T cell development. (360G-Wellcome-077995_Z_05_Z)

£302,561

The thymus, the primary site of T cell production, is seeded throughout life by blood borne lymphocyte progenitor cells from the foetal liver or adult bone marrow. This project aims to test the hypothesis that the Bone Morphogenetic Protein (BMP) 2 and 4 signalling pathway is an important regulator of haematopoiesis and thymopoiesis. The BMP family of secreted intercellular signalling molecules are powerful regulators of patterning and organogenesis of many mammalian tissues during embryonic development, but relatively little is known about the function of BMP signalling in the immune system. To avoid complications of redundancy and promiscuity between components of the signalling pathway, we will focus on the type I BMP Receptors for BMP2 and BMP4: BMPR1A and BMPR1B. We will use conditional BMPR1A knock-out mice to study the function of BMP signalling in haematopoietic stem cells and lymphocyte progenitor cells and developing thymocytes. As BMPR1B-/- are viable, we will use these animals to investigate the function of BMPR1B in lymphocyte progenitor cells and developing T cells. Key goals: (1) To define the functions of BMP2/4 signalling in thymocyte development(2) To elucidate molecular mechanisms that underlie these functions(3) To identify target genes that are transcriptionally regulated by the pathway.

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Grant Details

Amount Awarded 302561
Applicant Surname Crompton
Approval Committee Immunology and Infectious Disease Funding Committee
Award Date 2005-10-25T00:00:00+00:00
Financial Year 2005/06
Grant Programme: Title Project Grant
Internal ID 077995/Z/05/Z
Lead Applicant Prof Tessa Crompton
Partnership Value 302561
Planned Dates: End Date 2010-03-31T00:00:00+00:00
Planned Dates: Start Date 2006-03-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London