Biomarkers for paediatric TB. (360G-Wellcome-078116_Z_05_Z)
There is an urgent need for new diagnostic methods for TB in children. In a pilot study, funded by the Wellcome Trust, we have found 4 serum protein biomarkers that discriminate between culture positive proven cases of paediatric TB from other infections/inflammatory conditions with a sensitivity and specificity of 92.3% and 94.3% respectively. With a view to developing a point of care (POC) test, we will identify the 4 biomarkers at the molecular level and determine whether they can be detected at sufficient sensitivity by immunological means. If so, then a POC test with great potential to save children's lives can be developed with confidence. Specifically our aims are:(1) The molecular identification of 4 serum biomarkers specific for paediatric TB that we have found in a cohort of Cape Town (South African) children.(2) Confirmation of biomarker identity by immunological and/or biochemical means.(3) Validation of biomarkers by ELISA as an initial step in developing an immunological based POC test for use in resource poor countries.
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Grant Details
| Amount Awarded | 110094 |
| Applicant Surname | Langford |
| Approval Committee | Immunology and Infectious Disease Funding Committee |
| Award Date | 2005-10-25T00:00:00+00:00 |
| Financial Year | 2005/06 |
| Grant Programme: Title | Project Grant |
| Internal ID | 078116/Z/05/Z |
| Lead Applicant | Prof Paul Langford |
| Other Applicant(s) | Prof Michael Levin |
| Partnership Value | 110094 |
| Planned Dates: End Date | 2007-06-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2006-01-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |