Role of Bone Morphogenic Protein 8b (BMP8b) in thermogenesis. (360G-Wellcome-078409_Z_05_Z)
Long-term success to treat obesity is dependent on strategies aimed at preventing the concomitant fall in energy expenditure associated with food restriction (5). Energy modifications geared toward increasing energy expenditure may provide an alternative, independent means of promoting weight loss or, even more importantly, of preventing weight regain. In this project we investigate Bone morphogenic protein 8b (BMP8b) function as a novel mechanism regulating peripheral mechanisms of mammalian thermogenesis and fuel partitioning as strategies to prevent obesity. Our hypotheses are that: a) BMP8b may be an activator of thermogenesis and fatty acid oxidation and therefore a potential therapeutic target for obesity and type 2 diabetes mellitus. b) BMP8b may redirect the differentiation of white adipocyte fat pads towards more pro-thermogenic brown adipose fat pads. and c) BMP8b may promote energy dissipation in the skeletal muscle. The specific aims of this proposal are: 1. To establish the role of BMP8b on global energy homeostasis: thermogenesis, obesity and insulin resistance. 2. To establish the role of BMP8b in white and brown adipogenesis.3. Identification of signalling mechanisms mediated by BMP8b in adipocytes and skeletal muscle. These objectives will be accomplished through a multiple integrated approach involving in vivo and in vitro strategies
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Grant Details
Amount Awarded | 175881 |
Applicant Surname | Vidal-Puig |
Approval Committee | Physiological Sciences Funding Committee |
Award Date | 2005-11-07T00:00:00+00:00 |
Financial Year | 2005/06 |
Grant Programme: Title | Project Grant |
Internal ID | 078409/Z/05/Z |
Lead Applicant | Prof Antonio Vidal-Puig |
Other Applicant(s) | Dr Marc Slawik, Prof Jaswinder Sethi, Prof Nicholas Morrell, Prof Sir Stephen O'Rahilly |
Partnership Value | 175881 |
Planned Dates: End Date | 2008-01-31T00:00:00+00:00 |
Planned Dates: Start Date | 2006-02-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |