Alcohol and mortality: from aetiology to intervention. (360G-Wellcome-078557_Z_05_Z)

In 2003 Russian male life expectancy was 58 years, below India, Pakistan and Bangladesh. Alcohol has been hypothesised to contribute to this low figure, inferred largely from analyses of the sharp fluctuations in Russian mortality since 1985. We have new evidence from a case-control study that hazardous drinking alone accounts for 40% of all deaths among men aged 25-54 years - equivalent to around 175,000 deaths per year for Russia as a whole. Autopsy studies will be undertaken to examine the pathological and bio-marker evidence of alcohol's contribution to deaths at working age. We propose to re-interview 1300 men recruited 30-months earlier as population-based controls. Self and proxy-reported alcohol consumption patterns will be collected, together with bio-markers of alcohol consumption and damage plus cardiovascular risk factors. This will provide a unique longitudinal perspective on changes in hazardous drinking patterns and their social and bio-medical correlates. Hazardous drinkers will be recruited into an exploratory trial of 'brief' interventions. The feasibility of full-scale prevention and treatment trials in routine settings (such as schools and clinics) to reduce hazardous drinking prevalence will be assessed. The programme will provide a context for capacity building in epidemiology and public health.

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Grant Details

Amount Awarded 878568
Applicant Surname Leon
Approval Committee Populations and Public Health Funding Committee
Award Date 2006-02-16T00:00:00+00:00
Financial Year 2005/06
Grant Programme: Title Programme Grant
Internal ID 078557/Z/05/Z
Lead Applicant Prof David Leon
Other Applicant(s) Dr M Vali, Prof Diana Elbourne, Prof Jim McCambridge, Prof Martin McKee
Partnership Value 878568
Planned Dates: End Date 2011-06-30T00:00:00+00:00
Planned Dates: Start Date 2006-07-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London