Genetic dissection of the mood-psychosis spectrum (360G-Wellcome-078901_B_05_Z)

£214,583

We propose a programme that builds upon our previous work in mood disorders and psychosis and encompasses clinical and laboratory aspects. We will recruit 600 individuals with an illness characterized by a mix of features typically found in schizophrenia and bipolar disorder - few such individuals have been collected in samples to date but are very important for understanding the relationship between mood disorder and psychosis. We will follow up (by questionnaire and interview) 3000 participants previously recruited to our studies - illness features may vary over time and up-to-date information optimizes analytic power. We will investigate genes already implicated in mood disorders or psychosis by detailed genetic study in 5000 individuals (diagnosed with bipolar disorder, schizophrenia, depression or controls). A major part of our programme is detailed study, within individuals representing a broad range of mood and psychotic illness, of genes implicated in the Wellcome Trust Case Control Consortium (WTCCC) study (a systematic study of the whole genome including 2000 bipolar cases and 3000 controls). In addition to analysing traditional diagnostic categories we will use statistical methods capable of identifying completely new approaches to diagnosis that are biologically valid - we view this as key to our programme. We will pilot new clinical approaches to diagnostic assessment in our clinics. Our focus throughout is on achieving clinically relevant outcomes over realistic timescales.

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Grant Details

Amount Awarded 214583
Applicant Surname Jones
Approval Committee Neurosciences And Mental Health
Award Date 2006-02-27T00:00:00+00:00
Financial Year 2005/06
Grant Programme: Title Programme Grant
Internal ID 078901/B/05/Z
Lead Applicant Prof Lisa Jones
Other Applicant(s) Prof Femi Oyebode, Prof George Kirov, Prof Ian Jones, Prof Michael O'Donovan, Prof Michael Owen, Prof Nicholas Craddock, Prof Peter Holmans
Partnership Value 214583
Planned Dates: End Date 2012-03-31T00:00:00+00:00
Planned Dates: Start Date 2006-04-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region West Midlands