Epigenetic control of gene activity and repression: Regional influence of large repetitive domains in mammals. (360G-Wellcome-079052_Z_06_Z)
The function of the mammalian genome is regulated by epigenetic modifications to DNA and chromatin that affect a wide range of processes including gene activity and repression and chromosome architecture. It is now well established that alterations in such genome modifications are associated with disease. Understanding and describing the epigenetic state of the normal mammalian genome is one of the big challenges in the post-genomic era and high-throughput genomic microarray-based approaches are currently being developed to determine the 'epigenome' and define the DNA sequences that direct epigenetic states. Repetitive sequences constitute around 45% of the mammalian genome and by their nature are intractable to genomic array analysis. Growing evidence suggests that in some contexts these sequences might define epigenetic processes, but little is known about the function of stretches of repeat sequence in mammals. Here we propose the deletion of a 250kb block of repetitive DNA located at the boundary of a mouse imprinted domain to assess its consequences for the establishment and maintenance of regional epigenetic modifications and for the epigenetic control of gene activity and repression. In particular, we will determine whether imprinting in the domain is affected and whether the repetitive DNA acts as a barrier preventing the spread of imprinting to adjacent regions.
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Grant Details
Amount Awarded | 192245 |
Applicant Surname | Ferguson-Smith |
Approval Committee | Molecules, Genes and Cells Funding Committee |
Award Date | 2006-02-21T00:00:00+00:00 |
Financial Year | 2005/06 |
Grant Programme: Title | Project Grant |
Internal ID | 079052/Z/06/Z |
Lead Applicant | Prof Anne Ferguson-Smith |
Partnership Value | 192245 |
Planned Dates: End Date | 2009-06-30T00:00:00+00:00 |
Planned Dates: Start Date | 2006-07-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |