An investigation of risk factors for and outcomes of hypermetropia in the 1958 British birth cohort. (360G-Wellcome-079488_Z_06_Z)

£51,674

About 5% of children, 7% of working-age adults and 20% of older people have hypermetropia (long-sight) of a severity that requires optical correction for normal visual development and subsequently for vision dependent activities of daily living such as education, occupation, driving, sports and other social activities. Although a common condition, with an important role in other eye diseases of childhood (especially strabismus and amblyopia) and of late adult life, there is a paucity of research on its causes and its attendant biomedical and social associations. A life-course approach to investigating risk factors for, and outcomes of, complex disease, well-established in other chronic disease epidemiology, is novel in ophthalmology. We propose to study the biological, environmental, and lifestyle factors which influence hypermetropia from birth to mid-adult life and its health and social outcomes at different ages in order to understand their influences on basic mechanisms underlying development of refractive error. Thus we anticipate that the findings will be relevant to clinical practice and to further research, both epidemiological and genetic, on refractive errors, to further improve strategies for prevention and treatment. The 1958 British birth cohort study offers unparalleled opportunities for such work, having proven to be a critically important resource for the longitudinal study of natural history, predictors and health and social outcomes of a diverse range of disorders.

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Grant Details

Amount Awarded 51674
Applicant Surname Rahi
Approval Committee Populations and Public Health Funding Committee
Award Date 2006-05-16T00:00:00+00:00
Financial Year 2005/06
Grant Programme: Title Project Grant
Internal ID 079488/Z/06/Z
Lead Applicant Prof Jugnoo Rahi
Other Applicant(s) Prof Catherine Peckham
Partnership Value 51674
Planned Dates: End Date 2007-06-30T00:00:00+00:00
Planned Dates: Start Date 2006-07-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London