Generation and characterisation of human monoclonal antibodies to highly pathogenic H5N1 viruses. (360G-Wellcome-079864_Z_06_Z)
New prophylactic and therapeutic strategies to combat human infections with highly pathogenic H5N1 influenza A viruses are urgently needed. This project will use immortalised memory B cells from Vietnamese adults who have recovered from infections with highly pathogenic H5N1 avian influenza A viruses as a basis for the production of human monoclonal antibodies (hMabs) specific to the H5 haemagglutinin (HA) antigen. Immortalised B cell clones that secrete hMabs specific for the H5 HA antigen will be identified by ELISA and in vitro virus neutralisation assays. The primary goal of this project is to identify broadly-reactive H5 HA-specific hMabs that prevent or modulate the course of established H5N1 influenza infection in mice. The genetic loci encoding hMabs with desirable in vitro and in vivo properties will be amplified, cloned and transfected into cell lines suitable for the large-scale production and purification of hMab.
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Grant Details
Amount Awarded | 385435 |
Applicant Surname | Simmons |
Approval Committee | Immunology and Infectious Disease Funding Committee |
Award Date | 2006-04-24T00:00:00+00:00 |
Financial Year | 2005/06 |
Grant Programme: Title | Project funding: Inactive scheme |
Internal ID | 079864/Z/06/Z |
Lead Applicant | Prof Cameron Simmons |
Other Applicant(s) | Dr Jeremy Farrar, Dr K Subbaroa, Prof Antonio Lanzavecchia, Prof Menno De Jong |
Partnership Value | 385435 |
Planned Dates: End Date | 2009-04-30T00:00:00+00:00 |
Planned Dates: Start Date | 2006-05-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South East |