The Cellular and Molecular Basis of Disease. (360G-Wellcome-080458_Z_06_Z)

£136,849

The molecular details of the processes involved in maintaining the identity of centromeric chromatin are only rudimentary understood, in part because it is currently impossible to specifically manipulate the microenvironment of single centromeres. Employing a novel Human Artificial Chromosome (HAC), we aim to analyse in detail how the epigenetic information at an operative centromere modulates centromere identity and function. This research will provide a crucial contribution to understanding the vital processes of sister chromatid segregation during mitosis, aberrant execution of which can result in birth defects and cancer. The following questions will be addressed: 1. Which histone modifications define a functional centromere? 2. Do these modifications change in the course of the cell cycle, conferring a temporal component to positional information? 3. How do specific histone modifications affect centromere function?

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Grant Details

Amount Awarded 136849
Applicant Surname Bergmann
Approval Committee Immunology and Infectious Disease Funding Committee
Award Date 2006-04-26T00:00:00+00:00
Financial Year 2005/06
Grant Programme: Title PhD Studentship (Basic)
Internal ID 080458/Z/06/Z
Lead Applicant Mr Jan Bergmann
Partnership Value 136849
Planned Dates: End Date 2010-09-30T00:00:00+00:00
Planned Dates: Start Date 2006-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Scotland
Sponsor(s) Prof Richard Maizels