The Cellular and Molecular Basis of Disease. (360G-Wellcome-080458_Z_06_Z)
The molecular details of the processes involved in maintaining the identity of centromeric chromatin are only rudimentary understood, in part because it is currently impossible to specifically manipulate the microenvironment of single centromeres. Employing a novel Human Artificial Chromosome (HAC), we aim to analyse in detail how the epigenetic information at an operative centromere modulates centromere identity and function. This research will provide a crucial contribution to understanding the vital processes of sister chromatid segregation during mitosis, aberrant execution of which can result in birth defects and cancer. The following questions will be addressed: 1. Which histone modifications define a functional centromere? 2. Do these modifications change in the course of the cell cycle, conferring a temporal component to positional information? 3. How do specific histone modifications affect centromere function?
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Grant Details
Amount Awarded | 136849 |
Applicant Surname | Bergmann |
Approval Committee | Immunology and Infectious Disease Funding Committee |
Award Date | 2006-04-26T00:00:00+00:00 |
Financial Year | 2005/06 |
Grant Programme: Title | PhD Studentship (Basic) |
Internal ID | 080458/Z/06/Z |
Lead Applicant | Mr Jan Bergmann |
Partnership Value | 136849 |
Planned Dates: End Date | 2010-09-30T00:00:00+00:00 |
Planned Dates: Start Date | 2006-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Scotland |
Sponsor(s) | Prof Richard Maizels |