Is subcortical input to the basal ganglia via the thalamus organised into parallel, functionally segregated channels ? (360G-Wellcome-080943_Z_06_Z)
Analysis of parallel, partially closed-loop projections connecting the cerebral cortex with the basal ganglia has been a dominant feature in basal ganglia research for the past 20 years. Although of comparable anatomical significance, input from the thalamus has received much less attention. The likely importance of this input was, however, emphasised in our recent proposal that a series of phylogenetically older, looped connections exist between the basal ganglia and important structures in the brainstem, including the midbrain superior colliculus (SC). A general feature of subcortical input to the basal ganglia (striatum) is that it arrives via relays in the thalamus (Appendix Fig 1). Thus, a direct test of the 'subcortical loops' hypothesis will determine whether the multiple thalamic relays that receive input from the SC and provide output to the striatum can be viewed as anatomically and functionally segregated channels. We propose a series of convergent anatomical, physiological and behavioural investigations to test this hypothesis. Given the evolutionary conserved nature of subcortical brain architecture, understanding this circuitry will help us appreciate how this currently poorly understood component of the basal ganglia might contribute to the basal ganglia-related dysfunctions that afflict humans.
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Grant Details
Amount Awarded | 334830 |
Applicant Surname | Redgrave |
Approval Committee | Neurosciences And Mental Health |
Award Date | 2006-10-12T00:00:00+00:00 |
Financial Year | 2006/07 |
Grant Programme: Title | Project Grant |
Internal ID | 080943/Z/06/Z |
Lead Applicant | Prof Peter Redgrave |
Other Applicant(s) | Prof Paul Overton |
Partnership Value | 334830 |
Planned Dates: End Date | 2011-01-31T00:00:00+00:00 |
Planned Dates: Start Date | 2007-03-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Yorkshire and the Humber |