Disrupting neuronal gene expression in vitro and in vivo using lentiviral vectors. (360G-Wellcome-080960_Z_06_A)
i) To use a lentiviral vector system to deliver shRNA to sensory neurons in vitro and in vivo, and to specifically disrupt target gene expression. (ii) To use viral vectors to study the involvement of particular proteins in pain pathways and elucidate the mechanisms by which these proteins contribute to chronic pain states (iii) To improve the lentiviral vector system by enhancing its target cell specificity by, for example, modifying the promoter driving the shRNA expression
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Grant Details
Amount Awarded | 10040 |
Applicant Surname | Heinzmann |
Approval Committee | Physiological Sciences Funding Committee |
Award Date | 2008-02-19T00:00:00+00:00 |
Financial Year | 2007/08 |
Grant Programme: Title | PhD Studentship (Basic) |
Internal ID | 080960/Z/06/A |
Lead Applicant | Mr Sebastian Heinzmann |
Partnership Value | 10040 |
Planned Dates: End Date | 2010-09-30T00:00:00+00:00 |
Planned Dates: Start Date | 2008-03-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |
Sponsor(s) | Prof Stephen McMahon |