Disrupting neuronal gene expression in vitro and in vivo using lentiviral vectors. (360G-Wellcome-080960_Z_06_A)

£10,040

i) To use a lentiviral vector system to deliver shRNA to sensory neurons in vitro and in vivo, and to specifically disrupt target gene expression. (ii) To use viral vectors to study the involvement of particular proteins in pain pathways and elucidate the mechanisms by which these proteins contribute to chronic pain states (iii) To improve the lentiviral vector system by enhancing its target cell specificity by, for example, modifying the promoter driving the shRNA expression

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Grant Details

Amount Awarded 10040
Applicant Surname Heinzmann
Approval Committee Physiological Sciences Funding Committee
Award Date 2008-02-19T00:00:00+00:00
Financial Year 2007/08
Grant Programme: Title PhD Studentship (Basic)
Internal ID 080960/Z/06/A
Lead Applicant Mr Sebastian Heinzmann
Partnership Value 10040
Planned Dates: End Date 2010-09-30T00:00:00+00:00
Planned Dates: Start Date 2008-03-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Stephen McMahon