The Consequences and Outcomes of Convulsive Status Epilepticus in Children. (360G-Wellcome-081207_Z_06_Z)

£310,759

The central hypothesis of this study is that convulsive status epilepticus (CSE) is associated with brain injury, particularly to the hippocampus, which predisposes individuals to subsequent development of epilepsy and associated neurodevelopmental and/or behavioural dysfunction. CSE is the most common medical neurological emergency in childhood with an incidence of 18-20/100,000 children per year. The possible adverse outcomes from childhood CSE include subsequent epilepsy, permanent neurol ogical, developmental or cognitive deficits, or death. The proposed study will characterise structural brain abnormalities and identify early predictors of adverse outcomes, with particular emphasis on the hippocampus and mesial temporal sclerosis (MTS). Understanding the genesis of MTS would provide a framework for development of strategies that could reduce morbidity associated with MTS. My previous studies have shown evidence of hippocampal oedema and evidence of longer-term hippocampal injur y 6 months following CSE, although not all of the magnetic resonance criteria for MTS have been met. In the work proposed, the natural history of MTS and other structural brain abnormalities will be investigated using longitudinal quantitative magnetic resonance imaging in children with CSE. Prediction of morbidities based on magnetic resonance parameters will allow early identification of children who would develop an adverse outcome and promote early treatment.

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Grant Details

Amount Awarded 310759
Applicant Surname Scott
Approval Committee Cognitive and Higher Systems Funding Committee
Award Date 2007-02-06T00:00:00+00:00
Financial Year 2006/07
Grant Programme: Title Project Grant
Internal ID 081207/Z/06/Z
Lead Applicant Dr Rodney Scott
Other Applicant(s) Dr Christopher Clark, Dr Wui Chong, Prof Brian Neville, Prof David Gadian
Partnership Value 310759
Planned Dates: End Date 2010-07-31T00:00:00+00:00
Planned Dates: Start Date 2007-08-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London