Genomic and biochemical analysis of ageing and age-related disease. (360G-Wellcome-081394_Z_06_Z)

£5,127,323

A recent discovery is that mutations in single genes can extend healthy lifespan in laboratory organisms. Furthermore, these effects are conserved over large evolutionary distances, opening the opportunity to use simpler organisms with much shorter lifespans to understand human ageing. Mutations in insulin/IGF-like signalling (IIS) genes can extend lifespan in the worm Caenorhabditis elegans, the fruit fly Drosophila and the mouse. Our collaborative research programme has three aims: 1. Our previous work has both demonstrated robust conservation of the effects of IIS on lifespan in Drosophila and produced a new, robustly long-lived mutant mouse. We shall unravel the signalling mechanisms involved, essential for identification of possible drug targets. 2. We shall identify and manipulate the biochemical processes by which IIS slows ageing, the key to understanding how ageing-related damage is generated and how normal longevity is assured by defence and repair systems. We shall focus on detoxification, autophagy and the proteasome. 3. Ageing is the major risk factor for predominant, lethal diseases: cardiovascular disease, cancer and neurodegenerative disease. We shall test the idea that ageing-related diseases are caused by the same accumulation of molecular damage that drives the ageing process, focussing upon neurodegenerative diseases in the model organisms and humans.

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Grant Details

Amount Awarded 5127323
Applicant Surname Partridge
Approval Committee Strategic Awards Committee
Award Date 2007-07-18T00:00:00+00:00
Financial Year 2006/07
Grant Programme: Title Strategic Award - Science
Internal ID 081394/Z/06/Z
Lead Applicant Prof Linda Partridge
Other Applicant(s) Prof David Gems, Prof Dominic Withers, Prof Janet Thornton
Partnership Value 5127323
Planned Dates: End Date 2014-10-31T00:00:00+00:00
Planned Dates: Start Date 2007-08-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London