The epidemiology, spatial ecology and transmission dynamics of co-infection with plasmodium falciparum and hookworm in East Africa (360G-Wellcome-081673_Z_06_A)

The epidemiology of plasmodia-helminth co-infection is poorly understood. This is despite increasing evidence that co-infection may enhance individual susceptibility to clinical malaria and recent advocacy for the logistical and economic benefits of integrated disease control targeting multiple parasites. This proposal details a range of field and modelling studies aimed at understanding the epidemiology, geography and transmission dynamics of co-infection with Plasmodium falciparum and hookworm in East African children. The proposed field studies will provide better descriptions of the patterns of transmission and the risk factors for co-infection in a variety of environmental and socio-economic settings. This information will be used to develop innovative geostatistical models to predict the spatial range of co-infection. Mathematical models will be developed of the dynamics of co-infection within communities in relation to key geographic heterogeneities and augmented with geostatistical models to determine the paediatric population at the risk of co-infection in East Africa. The resulting products will provide decision-makers with better information with which to design integrated disease control strategies in the region. They will also provide a credible academic framework for future work on the individual, population and thus public health consequences of co-infection.

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Grant Details

Amount Awarded 25953
Applicant Surname Brooker
Approval Committee Immunology and Infectious Disease Funding Committee
Award Date 2009-05-29T00:00:00+00:00
Financial Year 2008/09
Grant Programme: Title Research Career Development Fellowship
Internal ID 081673/Z/06/A
Lead Applicant Prof Simon Brooker
Partnership Value 25953
Planned Dates: End Date 2012-07-31T00:00:00+00:00
Planned Dates: Start Date 2009-06-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Fred Wabwire-Mangen, Prof Hazel Dockrell, Prof Robert Snow