How do pattern defects cause apoptosis in developing tissues?. (360G-Wellcome-082694_Z_07_Z)

£250,000

Tissue homeostasis depends on the appropriate integration of cell proliferation, cell differentiation and apoptosis. The apoptosis program is activated to remove superfluous, mis-specified, or genetically damaged cells. I plan to investigate the mechanisms that activate apoptosis in cells that are mis-specified during development. To address this question, I will first determine the spatial pattern of cell death in Drosophila embryos in response to the lack or excess of Wingless signalling. I wi ll also look at the behaviour of these cells under conditions that prevent them from undergoing apoptosis. In parallel, I will use existing databases and microarray analysis to search for genes that could mediate the response to mis-specification. One possibility is that cell surface molecules will be involved, allowing cells to display and compare their state of specification within a field. I expect such genes as well as genes encoding components of the signal transduction machinery to come ou t of my search At the end of my fellowship I will initiate the functional analysis of these genes.

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Grant Details

Amount Awarded 250000
Applicant Surname Baena Lopez
Approval Committee Sir Henry Wellcome Postdoctoral Fellowships Interview Committee
Award Date 2007-05-30T00:00:00+00:00
Financial Year 2006/07
Grant Programme: Title Sir Henry Wellcome Postdoctoral Fellowship
Internal ID 082694/Z/07/Z
Lead Applicant Dr Luis Baena Lopez
Partnership Value 250000
Planned Dates: End Date 2012-03-31T00:00:00+00:00
Planned Dates: Start Date 2008-04-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South West
Sponsor(s) Prof David Wilkinson